Antisense transcription of the myotonic dystrophy locus yields low-abundant RNAs with and without (CAG)n repeat

The unstable (CTG·CAG)n trinucleotide repeat in the myotonic dystrophy type 1 (DM1) locus is bidirectionally transcribed from genes with terminal overlap. By transcription in the sense direction, the DMPK gene produces various alternatively spliced mRNAs with a (CUG)n repeat in their 3′ UTR. Express...

Descripción completa

Detalles Bibliográficos
Autores principales: Gudde, Anke E. E. G., van Heeringen, Simon J., de Oude, Amanda I., van Kessel, Ingeborg D. G., Estabrook, Joseph, Wang, Eric T., Wieringa, Bé, Wansink, Derick G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711456/
https://www.ncbi.nlm.nih.gov/pubmed/28102759
http://dx.doi.org/10.1080/15476286.2017.1279787

Ejemplares similares

Ejemplares similares