Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report

We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resi...

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Detalles Bibliográficos
Autores principales: Vettorato, Rodrigo, Heidrich, Daiane, Fraga, Fernanda, Ribeiro, Amanda Carvalho, Pagani, Danielle Machado, Timotheo, Carina, Amaro, Tais Guarienti, Vettorato, Gerson, Scroferneker, Maria Lúcia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711665/
https://www.ncbi.nlm.nih.gov/pubmed/29204336
http://dx.doi.org/10.1016/j.mmcr.2017.10.001
Descripción
Sumario:We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. The lesions did not regress with itraconazole treatment. Thus, 500 mg/day of terbinafine was prescribed and clinical cure was obtained after four months

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