Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report

We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resi...

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Autores principales: Vettorato, Rodrigo, Heidrich, Daiane, Fraga, Fernanda, Ribeiro, Amanda Carvalho, Pagani, Danielle Machado, Timotheo, Carina, Amaro, Tais Guarienti, Vettorato, Gerson, Scroferneker, Maria Lúcia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711665/
https://www.ncbi.nlm.nih.gov/pubmed/29204336
http://dx.doi.org/10.1016/j.mmcr.2017.10.001
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author Vettorato, Rodrigo
Heidrich, Daiane
Fraga, Fernanda
Ribeiro, Amanda Carvalho
Pagani, Danielle Machado
Timotheo, Carina
Amaro, Tais Guarienti
Vettorato, Gerson
Scroferneker, Maria Lúcia
author_facet Vettorato, Rodrigo
Heidrich, Daiane
Fraga, Fernanda
Ribeiro, Amanda Carvalho
Pagani, Danielle Machado
Timotheo, Carina
Amaro, Tais Guarienti
Vettorato, Gerson
Scroferneker, Maria Lúcia
author_sort Vettorato, Rodrigo
collection PubMed
description We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. The lesions did not regress with itraconazole treatment. Thus, 500 mg/day of terbinafine was prescribed and clinical cure was obtained after four months
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spelling pubmed-57116652017-12-04 Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report Vettorato, Rodrigo Heidrich, Daiane Fraga, Fernanda Ribeiro, Amanda Carvalho Pagani, Danielle Machado Timotheo, Carina Amaro, Tais Guarienti Vettorato, Gerson Scroferneker, Maria Lúcia Med Mycol Case Rep Case Report We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. The lesions did not regress with itraconazole treatment. Thus, 500 mg/day of terbinafine was prescribed and clinical cure was obtained after four months Elsevier 2017-10-28 /pmc/articles/PMC5711665/ /pubmed/29204336 http://dx.doi.org/10.1016/j.mmcr.2017.10.001 Text en © 2017 Published by Elsevier B.V. on behalf of International Society for Human and Animal Mycology. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Vettorato, Rodrigo
Heidrich, Daiane
Fraga, Fernanda
Ribeiro, Amanda Carvalho
Pagani, Danielle Machado
Timotheo, Carina
Amaro, Tais Guarienti
Vettorato, Gerson
Scroferneker, Maria Lúcia
Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report
title Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report
title_full Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report
title_fullStr Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report
title_full_unstemmed Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report
title_short Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report
title_sort sporotrichosis by sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711665/
https://www.ncbi.nlm.nih.gov/pubmed/29204336
http://dx.doi.org/10.1016/j.mmcr.2017.10.001
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