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An improved solvent-free synthesis of flunixin and 2-(arylamino) nicotinic acid derivatives using boric acid as catalyst

A simple solvent-free protocol for the preparation of flunixin, a potent non-narcotic, non-steroidal anti-inflammatory drugs is reported using boric acid as catalyst. Its salt, flunixin meglumine are then prepared under reflux in EtOH. This sustainable method are then extended for the synthesis of a...

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Detalles Bibliográficos
Autores principales:	Yarhosseini, Mahsa, Javanshir, Shahrzad, Dolatkhah, Zahra, Dekamin, Mohammad G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711764/ https://www.ncbi.nlm.nih.gov/pubmed/29196901 http://dx.doi.org/10.1186/s13065-017-0355-4

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