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Solitary Extramedullary Plasmacytoma of the Cricoid Cartilage—Case Report
Solitary plasmacytoma (SP) is an extremely rare form of hematologic malignancy that can be classified as solitary bone plasmacytoma or solitary extramedullary plasmacytoma. Here, we report a patient who presented with progressive shortness of breath and foreign body sensation in his throat. Fluorode...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711767/ https://www.ncbi.nlm.nih.gov/pubmed/29230383 http://dx.doi.org/10.3389/fonc.2017.00284 |
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author | Krebs, Simone Ganly, Ian Ghossein, Ronald Yang, Joanna Yahalom, Joachim Schöder, Heiko |
author_facet | Krebs, Simone Ganly, Ian Ghossein, Ronald Yang, Joanna Yahalom, Joachim Schöder, Heiko |
author_sort | Krebs, Simone |
collection | PubMed |
description | Solitary plasmacytoma (SP) is an extremely rare form of hematologic malignancy that can be classified as solitary bone plasmacytoma or solitary extramedullary plasmacytoma. Here, we report a patient who presented with progressive shortness of breath and foreign body sensation in his throat. Fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) demonstrated an abnormal FDG-avid soft tissue mass arising from the larynx involving the cricoid cartilage without additional suspicious lesions. Histology revealed an abundance of plasma cells; immunohistochemistry was positive for CD138 expression and lambda chains, and negative for CD20. Comprehensive imaging studies and panendoscopy of the ENT tract confirmed solitary disease involvement. Following additional systemic work-up, a diagnosis of extramedullary plasmacytoma was rendered. The patient underwent definitive radiotherapy using intensity-modulated radiation therapy (total dose of 46 Gy, divided in 23 fractions of 200 cGy). Serial PET/CT showed the stepwise resolution of abnormal FDG uptake and resolution of the cricoid cartilage lesion. With 22 months of follow-up, the patient remains free of disease. We describe the rare case of SP presenting as a FDG-avid hypermetabolic soft tissue mass in the cricoid cartilage, which should be considered in the differential diagnosis of laryngeal tumors. Of note, SP is radiosensitive; favorable outcome can be expected once treated with doses of 40–50 Gy. FDG PET/CT is helpful in diagnosis and response assessment for this disease. |
format | Online Article Text |
id | pubmed-5711767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57117672017-12-11 Solitary Extramedullary Plasmacytoma of the Cricoid Cartilage—Case Report Krebs, Simone Ganly, Ian Ghossein, Ronald Yang, Joanna Yahalom, Joachim Schöder, Heiko Front Oncol Oncology Solitary plasmacytoma (SP) is an extremely rare form of hematologic malignancy that can be classified as solitary bone plasmacytoma or solitary extramedullary plasmacytoma. Here, we report a patient who presented with progressive shortness of breath and foreign body sensation in his throat. Fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) demonstrated an abnormal FDG-avid soft tissue mass arising from the larynx involving the cricoid cartilage without additional suspicious lesions. Histology revealed an abundance of plasma cells; immunohistochemistry was positive for CD138 expression and lambda chains, and negative for CD20. Comprehensive imaging studies and panendoscopy of the ENT tract confirmed solitary disease involvement. Following additional systemic work-up, a diagnosis of extramedullary plasmacytoma was rendered. The patient underwent definitive radiotherapy using intensity-modulated radiation therapy (total dose of 46 Gy, divided in 23 fractions of 200 cGy). Serial PET/CT showed the stepwise resolution of abnormal FDG uptake and resolution of the cricoid cartilage lesion. With 22 months of follow-up, the patient remains free of disease. We describe the rare case of SP presenting as a FDG-avid hypermetabolic soft tissue mass in the cricoid cartilage, which should be considered in the differential diagnosis of laryngeal tumors. Of note, SP is radiosensitive; favorable outcome can be expected once treated with doses of 40–50 Gy. FDG PET/CT is helpful in diagnosis and response assessment for this disease. Frontiers Media S.A. 2017-11-27 /pmc/articles/PMC5711767/ /pubmed/29230383 http://dx.doi.org/10.3389/fonc.2017.00284 Text en Copyright © 2017 Krebs, Ganly, Ghossein, Yang, Yahalom and Schöder. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Krebs, Simone Ganly, Ian Ghossein, Ronald Yang, Joanna Yahalom, Joachim Schöder, Heiko Solitary Extramedullary Plasmacytoma of the Cricoid Cartilage—Case Report |
title | Solitary Extramedullary Plasmacytoma of the Cricoid Cartilage—Case Report |
title_full | Solitary Extramedullary Plasmacytoma of the Cricoid Cartilage—Case Report |
title_fullStr | Solitary Extramedullary Plasmacytoma of the Cricoid Cartilage—Case Report |
title_full_unstemmed | Solitary Extramedullary Plasmacytoma of the Cricoid Cartilage—Case Report |
title_short | Solitary Extramedullary Plasmacytoma of the Cricoid Cartilage—Case Report |
title_sort | solitary extramedullary plasmacytoma of the cricoid cartilage—case report |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711767/ https://www.ncbi.nlm.nih.gov/pubmed/29230383 http://dx.doi.org/10.3389/fonc.2017.00284 |
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