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Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice

Well-ordered soluble HIV-1 envelope glycoprotein (Env) spike mimetics such as Native Flexibly Linked (NFL) trimers display high homogeneity, desired antigenicity, and high in vitro stability compared to previous generation soluble HIV-1 Env trimers. Glutaraldehyde (GLA) cross-linking was shown to fu...

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Detalles Bibliográficos
Autores principales:	Soldemo, Martina, Àdori, Monika, Stark, Julian M., Feng, Yu, Tran, Karen, Wilson, Richard, Yang, Lifei, Guenaga, Javier, Wyatt, Richard T., Karlsson Hedestam, Gunilla B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711779/ https://www.ncbi.nlm.nih.gov/pubmed/29230223 http://dx.doi.org/10.3389/fimmu.2017.01654

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