Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells

Current induction methods of hepatocytes from human induced pluripotent stem cells (hiPSCs) are neither low cost nor stable. By screening a chemical library of 1,120 bioactive compounds and known drugs, we identified the α1-adrenergic receptor agonist methoxamine hydrochloride as a small molecule th...

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Detalles Bibliográficos
Autores principales: Kotaka, Maki, Toyoda, Taro, Yasuda, Katsutaro, Kitano, Yuko, Okada, Chihiro, Ohta, Akira, Watanabe, Akira, Uesugi, Motonari, Osafune, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711806/
https://www.ncbi.nlm.nih.gov/pubmed/29196668
http://dx.doi.org/10.1038/s41598-017-16858-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711806/
https://www.ncbi.nlm.nih.gov/pubmed/29196668
http://dx.doi.org/10.1038/s41598-017-16858-5

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