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Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer

Hypoxia-inducible factor 1 alpha (HIF-1α) orchestrates cellular adaptation to low oxygen and nutrient-deprived environment and drives progression to malignancy in human solid cancers. Its canonical regulation involves prolyl hydroxylases (PHDs), which in normoxia induce degradation, whereas in hypox...

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Detalles Bibliográficos
Autores principales:	Iommarini, Luisa, Porcelli, Anna Maria, Gasparre, Giuseppe, Kurelac, Ivana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711814/ https://www.ncbi.nlm.nih.gov/pubmed/29230384 http://dx.doi.org/10.3389/fonc.2017.00286

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