Lck is a relevant target in chronic lymphocytic leukaemia cells whose expression variance is unrelated to disease outcome

Pathogenesis of chronic lymphocytic leukaemia (CLL) is contingent upon antigen receptor (BCR) expressed by malignant cells of this disease. Studies on somatic hypermutation of the antigen binding region, receptor expression levels and signal capacity have all linked BCR on CLL cells to disease progn...

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Detalles Bibliográficos
Autores principales: Till, Kathleen J., Allen, John C., Talab, Fatima, Lin, Ke, Allsup, David, Cawkwell, Lynn, Bentley, Alison, Ringshausen, Ingo, Duckworth, Andrew D., Pettitt, Andrew R., Kalakonda, Nagesh, Slupsky, Joseph R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711840/
https://www.ncbi.nlm.nih.gov/pubmed/29196709
http://dx.doi.org/10.1038/s41598-017-17021-w

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