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Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility
Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 contr...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711884/ https://www.ncbi.nlm.nih.gov/pubmed/29196614 http://dx.doi.org/10.1038/s41467-017-00320-1 |
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| author | Sud, Amit Thomsen, Hauke Law, Philip J. Försti, Asta Filho, Miguel Inacio da Silva Holroyd, Amy Broderick, Peter Orlando, Giulia Lenive, Oleg Wright, Lauren Cooke, Rosie Easton, Douglas Pharoah, Paul Dunning, Alison Peto, Julian Canzian, Federico Eeles, Rosalind Kote-Jarai, ZSofia Muir, Kenneth Pashayan, Nora Hoffmann, Per Nöthen, Markus M. Jöckel, Karl-Heinz Strandmann, Elke Pogge von Lightfoot, Tracy Kane, Eleanor Roman, Eve Lake, Annette Montgomery, Dorothy Jarrett, Ruth F. Swerdlow, Anthony J. Engert, Andreas Orr, Nick Hemminki, Kari Houlston, Richard S. |
| author_facet | Sud, Amit Thomsen, Hauke Law, Philip J. Försti, Asta Filho, Miguel Inacio da Silva Holroyd, Amy Broderick, Peter Orlando, Giulia Lenive, Oleg Wright, Lauren Cooke, Rosie Easton, Douglas Pharoah, Paul Dunning, Alison Peto, Julian Canzian, Federico Eeles, Rosalind Kote-Jarai, ZSofia Muir, Kenneth Pashayan, Nora Hoffmann, Per Nöthen, Markus M. Jöckel, Karl-Heinz Strandmann, Elke Pogge von Lightfoot, Tracy Kane, Eleanor Roman, Eve Lake, Annette Montgomery, Dorothy Jarrett, Ruth F. Swerdlow, Anthony J. Engert, Andreas Orr, Nick Hemminki, Kari Houlston, Richard S. |
| author_sort | Sud, Amit |
| collection | PubMed |
| description | Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 × 10(−8)) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10(−17)), 6q23.3 (rs6928977, P = 4.62 × 10(−11)), 10p14 (rs3781093, P = 9.49 × 10(−13)), 13q34 (rs112998813, P = 4.58 × 10(−8)) and 16p13.13 (rs34972832, P = 2.12 × 10(−8)). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response. |
| format | Online Article Text |
| id | pubmed-5711884 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-57118842017-12-05 Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility Sud, Amit Thomsen, Hauke Law, Philip J. Försti, Asta Filho, Miguel Inacio da Silva Holroyd, Amy Broderick, Peter Orlando, Giulia Lenive, Oleg Wright, Lauren Cooke, Rosie Easton, Douglas Pharoah, Paul Dunning, Alison Peto, Julian Canzian, Federico Eeles, Rosalind Kote-Jarai, ZSofia Muir, Kenneth Pashayan, Nora Hoffmann, Per Nöthen, Markus M. Jöckel, Karl-Heinz Strandmann, Elke Pogge von Lightfoot, Tracy Kane, Eleanor Roman, Eve Lake, Annette Montgomery, Dorothy Jarrett, Ruth F. Swerdlow, Anthony J. Engert, Andreas Orr, Nick Hemminki, Kari Houlston, Richard S. Nat Commun Article Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 × 10(−8)) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10(−17)), 6q23.3 (rs6928977, P = 4.62 × 10(−11)), 10p14 (rs3781093, P = 9.49 × 10(−13)), 13q34 (rs112998813, P = 4.58 × 10(−8)) and 16p13.13 (rs34972832, P = 2.12 × 10(−8)). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response. Nature Publishing Group UK 2017-12-01 /pmc/articles/PMC5711884/ /pubmed/29196614 http://dx.doi.org/10.1038/s41467-017-00320-1 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Sud, Amit Thomsen, Hauke Law, Philip J. Försti, Asta Filho, Miguel Inacio da Silva Holroyd, Amy Broderick, Peter Orlando, Giulia Lenive, Oleg Wright, Lauren Cooke, Rosie Easton, Douglas Pharoah, Paul Dunning, Alison Peto, Julian Canzian, Federico Eeles, Rosalind Kote-Jarai, ZSofia Muir, Kenneth Pashayan, Nora Hoffmann, Per Nöthen, Markus M. Jöckel, Karl-Heinz Strandmann, Elke Pogge von Lightfoot, Tracy Kane, Eleanor Roman, Eve Lake, Annette Montgomery, Dorothy Jarrett, Ruth F. Swerdlow, Anthony J. Engert, Andreas Orr, Nick Hemminki, Kari Houlston, Richard S. Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility |
| title | Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility |
| title_full | Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility |
| title_fullStr | Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility |
| title_full_unstemmed | Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility |
| title_short | Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility |
| title_sort | genome-wide association study of classical hodgkin lymphoma identifies key regulators of disease susceptibility |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711884/ https://www.ncbi.nlm.nih.gov/pubmed/29196614 http://dx.doi.org/10.1038/s41467-017-00320-1 |
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