The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover

Increasing evidence implicates serine proteinases in the proteolytic cascades leading to the pathological destruction of extracellular matrices such as cartilage in osteoarthritis (OA). We have previously demonstrated that the type II transmembrane serine proteinase (TTSP) matriptase acts as a novel...

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Detalles Bibliográficos
Autores principales: Wilkinson, David J., Desilets, Antoine, Lin, Hua, Charlton, Sarah, del Carmen Arques, Maria, Falconer, Adrian, Bullock, Craig, Hsu, Yu-Chen, Birchall, Kristian, Hawkins, Alastair, Thompson, Paul, Ferrell, William R., Lockhart, John, Plevin, Robin, Zhang, Yadan, Blain, Emma, Lin, Shu-Wha, Leduc, Richard, Milner, Jennifer M., Rowan, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711915/
https://www.ncbi.nlm.nih.gov/pubmed/29196708
http://dx.doi.org/10.1038/s41598-017-17028-3

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