Cargando…

Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity

Light chain amyloidosis (AL), the most common systemic amyloidosis, is caused by the overproduction and the aggregation of monoclonal immunoglobulin light chains (LC) in target organs. Due to genetic rearrangement and somatic hypermutation, virtually, each AL patient presents a different amyloidogen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oberti, Luca, Rognoni, Paola, Barbiroli, Alberto, Lavatelli, Francesca, Russo, Rosaria, Maritan, Martina, Palladini, Giovanni, Bolognesi, Martino, Merlini, Giampaolo, Ricagno, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711917/ https://www.ncbi.nlm.nih.gov/pubmed/29196671 http://dx.doi.org/10.1038/s41598-017-16953-7

Ejemplares similares

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient
por: Swuec, Paolo, et al.
Publicado: (2019)

Protease‐sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation
por: Mazzini, Giulia, et al.
Publicado: (2021)

A Strategy for Synthesis of Pathogenic Human Immunoglobulin Free Light Chains in E. coli
por: Rognoni, Paola, et al.
Publicado: (2013)

Cu(II) Binding Increases the Soluble Toxicity of Amyloidogenic Light Chains
por: Russo, Rosaria, et al.
Publicado: (2022)

Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis: insights into the timing of proteolysis
por: Lavatelli, Francesca, et al.
Publicado: (2021)

In situ characterization of protein aggregates in human tissues affected by light chain amyloidosis: a FTIR microspectroscopy study
por: Ami, Diletta, et al.
Publicado: (2016)

A covalent homodimer probing early oligomers along amyloid aggregation
por: Halabelian, Levon, et al.
Publicado: (2015)

Dissecting the Molecular Features of Systemic Light Chain (AL) Amyloidosis: Contributions from Proteomics
por: Rognoni, Paola, et al.
Publicado: (2021)

Systemic amyloidoses and proteomics: The state of the art
por: Lavatelli, Francesca, et al.
Publicado: (2016)

Light Chain Amyloidosis
por: Milani, Paolo, et al.
Publicado: (2018)

Novel Therapies in Light Chain Amyloidosis
por: Milani, Paolo, et al.
Publicado: (2017)

Proteotoxicity in cardiac amyloidosis: amyloidogenic light chains affect the levels of intracellular proteins in human heart cells
por: Imperlini, Esther, et al.
Publicado: (2017)

Daratumumab in the Treatment of Light-Chain (AL) Amyloidosis
por: Palladini, Giovanni, et al.
Publicado: (2021)

Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter
por: Schulte, Tim, et al.
Publicado: (2022)

Decoding the Structural Bases of D76N ß2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis
por: de Rosa, Matteo, et al.
Publicado: (2015)

Indicators of profound hematologic response in AL amyloidosis: complete response remains the goal of therapy
por: Milani, Paolo, et al.
Publicado: (2020)

Glycosylation Tunes Neuroserpin Physiological and Pathological Properties
por: Visentin, Cristina, et al.
Publicado: (2020)

The lung in amyloidosis
por: Milani, Paolo, et al.
Publicado: (2017)

Embelin binds to human neuroserpin and impairs its polymerisation
por: Saga, Giorgia, et al.
Publicado: (2016)

Amyloidogenic light chains impair plasma cell survival
por: Pick, Marjorie, et al.
Publicado: (2023)

Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity
por: Le Marchand, Tanguy, et al.
Publicado: (2018)

Targeting Amyloid Fibrils by Passive Immunotherapy in Systemic Amyloidosis
por: Nuvolone, Mario, et al.
Publicado: (2022)

Oral Therapy for the Treatment of Transthyretin-Related Amyloid Cardiomyopathy
por: Nuvolone, Mario, et al.
Publicado: (2022)

Sars-Cov-2 Infection and Systemic Light Chain Amyloidosis: The International Society of Amyloidosis' Survey
por: Milani, Paolo, et al.
Publicado: (2020)

Clinical Amyloid Typing by Proteomics: Performance Evaluation and Data Sharing between Two Centres
por: Canetti, Diana, et al.
Publicado: (2021)

Biochemical and biophysical characterisation of immunoglobulin free light chains derived from an initially unbiased population of patients with light chain disease
por: Sternke-Hoffmann, Rebecca, et al.
Publicado: (2020)

Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3
por: Garcia-Pardo, Javier, et al.
Publicado: (2023)

Embelin as Lead Compound for New Neuroserpin Polymerization Inhibitors
por: Visentin, Cristina, et al.
Publicado: (2020)

Proposed Cardiac End Points for Clinical Trials in Immunoglobulin Light Chain Amyloidosis: Report From the Amyloidosis Forum Cardiac Working Group
por: Maurer, Mathew S., et al.
Publicado: (2022)

PB2151: CLINICAL FEATURES AND OUTCOMES OF DIFFUSE PULMONARY LIGHT CHAIN AMYLOIDOSIS: A RARE PRESENTATION OF SYSTEMIC AL AMYLOIDOSIS
por: Chakraborty, Rajshekhar, et al.
Publicado: (2023)

Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability
por: Camilloni, Carlo, et al.
Publicado: (2016)

AA-amyloidosis in cats (Felis catus) housed in shelters
por: Ferri, Filippo, et al.
Publicado: (2023)

The CDR1 and Other Regions of Immunoglobulin Light Chains are Hot Spots for Amyloid Aggregation
por: Ruiz-Zamora, Robin Axel, et al.
Publicado: (2019)

Amyloid cranial polyneuropathy: A rare neurological presentation of immunoglobulin light‐chain amyloidosis
por: Agarwal, Abhinav, et al.
Publicado: (2021)

Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant
por: Bonì, Francesco, et al.
Publicado: (2016)

Biochemical and biophysical characterization of pathological aggregation of amyloid proteins
por: Long, Houfang, et al.
Publicado: (2022)

A Strategy for the Selection of RT-qPCR Reference Genes Based on Publicly Available Transcriptomic Datasets
por: Nevone, Alice, et al.
Publicado: (2023)

Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain
por: Brumshtein, Boris, et al.
Publicado: (2015)

Quality of life assessment in amyloid transthyretin (ATTR) amyloidosis
por: Aimo, Alberto, et al.
Publicado: (2021)

Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques
por: Ereño-Orbea, June, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_5ibhg7ecrf7tk5dhor7r2ak0a5