Blood Serum Calorimetry Indicates the Chemotherapeutic Efficacy in Lung Cancer Treatment

Chemotherapy is a primary treatment for the metastatic lung cancer patients. To select the most effective combination of drugs, we need an efficient way of assessing tumor response. Here, we showed that differential scanning calorimetry (DSC) analysis of blood serum proteins could reveal the patient...

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Autores principales: Kędra-Królik, Karolina, Chmielewska, Izabela, Michnik, Anna, Zarzycki, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711924/
https://www.ncbi.nlm.nih.gov/pubmed/29196643
http://dx.doi.org/10.1038/s41598-017-17004-x
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author Kędra-Królik, Karolina
Chmielewska, Izabela
Michnik, Anna
Zarzycki, Piotr
author_facet Kędra-Królik, Karolina
Chmielewska, Izabela
Michnik, Anna
Zarzycki, Piotr
author_sort Kędra-Królik, Karolina
collection PubMed
description Chemotherapy is a primary treatment for the metastatic lung cancer patients. To select the most effective combination of drugs, we need an efficient way of assessing tumor response. Here, we showed that differential scanning calorimetry (DSC) analysis of blood serum proteins could reveal the patient response to the treatment. If chemotherapy is effective, serum proteins DSC curve of non-small cellular lung cancer (NSCLC) case is similar to the those of the healthy individuals. If treatment fails, notable changes occur in the DSC profile of NSCLC patient’s blood serum. Our preliminary work illustrates how thermal analysis of changes in the heat capacity of blood serum proteins can provide an insight into patient response to chemotherapy – the essential information for any successive lung cancer treatment.
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spelling pubmed-57119242017-12-06 Blood Serum Calorimetry Indicates the Chemotherapeutic Efficacy in Lung Cancer Treatment Kędra-Królik, Karolina Chmielewska, Izabela Michnik, Anna Zarzycki, Piotr Sci Rep Article Chemotherapy is a primary treatment for the metastatic lung cancer patients. To select the most effective combination of drugs, we need an efficient way of assessing tumor response. Here, we showed that differential scanning calorimetry (DSC) analysis of blood serum proteins could reveal the patient response to the treatment. If chemotherapy is effective, serum proteins DSC curve of non-small cellular lung cancer (NSCLC) case is similar to the those of the healthy individuals. If treatment fails, notable changes occur in the DSC profile of NSCLC patient’s blood serum. Our preliminary work illustrates how thermal analysis of changes in the heat capacity of blood serum proteins can provide an insight into patient response to chemotherapy – the essential information for any successive lung cancer treatment. Nature Publishing Group UK 2017-12-01 /pmc/articles/PMC5711924/ /pubmed/29196643 http://dx.doi.org/10.1038/s41598-017-17004-x Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kędra-Królik, Karolina
Chmielewska, Izabela
Michnik, Anna
Zarzycki, Piotr
Blood Serum Calorimetry Indicates the Chemotherapeutic Efficacy in Lung Cancer Treatment
title Blood Serum Calorimetry Indicates the Chemotherapeutic Efficacy in Lung Cancer Treatment
title_full Blood Serum Calorimetry Indicates the Chemotherapeutic Efficacy in Lung Cancer Treatment
title_fullStr Blood Serum Calorimetry Indicates the Chemotherapeutic Efficacy in Lung Cancer Treatment
title_full_unstemmed Blood Serum Calorimetry Indicates the Chemotherapeutic Efficacy in Lung Cancer Treatment
title_short Blood Serum Calorimetry Indicates the Chemotherapeutic Efficacy in Lung Cancer Treatment
title_sort blood serum calorimetry indicates the chemotherapeutic efficacy in lung cancer treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711924/
https://www.ncbi.nlm.nih.gov/pubmed/29196643
http://dx.doi.org/10.1038/s41598-017-17004-x
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