A Ser75-to-Asp phospho-mimicking mutation in Src accelerates ageing-related loss of retinal ganglion cells in mice

Src knockout mice show no detectable abnormalities in central nervous system (CNS) post-mitotic neurons, likely reflecting functional compensation by other Src family kinases. Cdk1- or Cdk5-dependent Ser75 phosphorylation in the amino-terminal Unique domain of Src, which shares no homology with othe...

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Detalles Bibliográficos
Autores principales: Kashiwagi, Kenji, Ito, Sadahiro, Maeda, Shuichiro, Kato, Goro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711949/
https://www.ncbi.nlm.nih.gov/pubmed/29196663
http://dx.doi.org/10.1038/s41598-017-16872-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711949/
https://www.ncbi.nlm.nih.gov/pubmed/29196663
http://dx.doi.org/10.1038/s41598-017-16872-7

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