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Ramadan Fasting Exerts Immunomodulatory Effects: Insights from a Systematic Review

Ramadan is the ninth month of the Islamic lunar calendar and is observed by Muslims as a month of fasting. All Muslim adults are expected to fast; nevertheless certain subgroups, including sick, frail subjects, and pregnant women, among others, are exempted. Ramadan fasting has been shown to impact...

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Autores principales: Adawi, Mohammad, Watad, Abdulla, Brown, Stav, Aazza, Khadija, Aazza, Hicham, Zouhir, Mohamed, Sharif, Kassem, Ghanayem, Khaled, Farah, Raymond, Mahagna, Hussein, Fiordoro, Stefano, Sukkar, Samir Giuseppe, Bragazzi, Nicola Luigi, Mahroum, Naim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712070/
https://www.ncbi.nlm.nih.gov/pubmed/29230208
http://dx.doi.org/10.3389/fimmu.2017.01144
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author Adawi, Mohammad
Watad, Abdulla
Brown, Stav
Aazza, Khadija
Aazza, Hicham
Zouhir, Mohamed
Sharif, Kassem
Ghanayem, Khaled
Farah, Raymond
Mahagna, Hussein
Fiordoro, Stefano
Sukkar, Samir Giuseppe
Bragazzi, Nicola Luigi
Mahroum, Naim
author_facet Adawi, Mohammad
Watad, Abdulla
Brown, Stav
Aazza, Khadija
Aazza, Hicham
Zouhir, Mohamed
Sharif, Kassem
Ghanayem, Khaled
Farah, Raymond
Mahagna, Hussein
Fiordoro, Stefano
Sukkar, Samir Giuseppe
Bragazzi, Nicola Luigi
Mahroum, Naim
author_sort Adawi, Mohammad
collection PubMed
description Ramadan is the ninth month of the Islamic lunar calendar and is observed by Muslims as a month of fasting. All Muslim adults are expected to fast; nevertheless certain subgroups, including sick, frail subjects, and pregnant women, among others, are exempted. Ramadan fasting has been shown to impact on body systems in different manners. The influence of Ramadan fasting on immune system regulation remains elusive; however, immune system changes, such as the modulation of body response to various infectious, stressful, and other harmful events, are of great interest during fasting. In this paper, we performed an extensive systematic literature review of different scholarly databases (ISI/Web of Science, Scopus, PubMed,/MEDLINE, Google Scholar, Directory of Open Access Journals, EbscoHOST, Scirus, Science Direct, the Cochrane Library, and ProQuest), using the following key words: “fasting,” “Ramadan,” “Islam,” and “immunity.” Conclusions drawn from these findings included: (1) Ramadan fasting has been shown to only mildly influence the immune system and the alterations induced are transient, returning to basal pre-Ramadan status shortly afterward. (2) Ramadan fasting during the second trimester of pregnancy was shown to be safe and did not result in negative fetal outcomes, or maternal oxidative status alterations. (3) In cardiac patients, Ramadan fasting can have beneficial effects including lipid profile improvement and alleviation of oxidative stress. (4) In asthmatic patients as well as in patients with human immunodeficiency virus/acquired immunodeficiency syndrome and autoimmune disorders, fasting was safe. (5) In psychiatric patients, such as those suffering from schizophrenia, fasting could increase immunologic markers. (6) Fasting Muslim athletes who maintain intensive training schedule during Ramadan showed fluctuations of immunologic markers.
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spelling pubmed-57120702017-12-11 Ramadan Fasting Exerts Immunomodulatory Effects: Insights from a Systematic Review Adawi, Mohammad Watad, Abdulla Brown, Stav Aazza, Khadija Aazza, Hicham Zouhir, Mohamed Sharif, Kassem Ghanayem, Khaled Farah, Raymond Mahagna, Hussein Fiordoro, Stefano Sukkar, Samir Giuseppe Bragazzi, Nicola Luigi Mahroum, Naim Front Immunol Immunology Ramadan is the ninth month of the Islamic lunar calendar and is observed by Muslims as a month of fasting. All Muslim adults are expected to fast; nevertheless certain subgroups, including sick, frail subjects, and pregnant women, among others, are exempted. Ramadan fasting has been shown to impact on body systems in different manners. The influence of Ramadan fasting on immune system regulation remains elusive; however, immune system changes, such as the modulation of body response to various infectious, stressful, and other harmful events, are of great interest during fasting. In this paper, we performed an extensive systematic literature review of different scholarly databases (ISI/Web of Science, Scopus, PubMed,/MEDLINE, Google Scholar, Directory of Open Access Journals, EbscoHOST, Scirus, Science Direct, the Cochrane Library, and ProQuest), using the following key words: “fasting,” “Ramadan,” “Islam,” and “immunity.” Conclusions drawn from these findings included: (1) Ramadan fasting has been shown to only mildly influence the immune system and the alterations induced are transient, returning to basal pre-Ramadan status shortly afterward. (2) Ramadan fasting during the second trimester of pregnancy was shown to be safe and did not result in negative fetal outcomes, or maternal oxidative status alterations. (3) In cardiac patients, Ramadan fasting can have beneficial effects including lipid profile improvement and alleviation of oxidative stress. (4) In asthmatic patients as well as in patients with human immunodeficiency virus/acquired immunodeficiency syndrome and autoimmune disorders, fasting was safe. (5) In psychiatric patients, such as those suffering from schizophrenia, fasting could increase immunologic markers. (6) Fasting Muslim athletes who maintain intensive training schedule during Ramadan showed fluctuations of immunologic markers. Frontiers Media S.A. 2017-11-27 /pmc/articles/PMC5712070/ /pubmed/29230208 http://dx.doi.org/10.3389/fimmu.2017.01144 Text en Copyright © 2017 Adawi, Watad, Brown, Aazza, Aazza, Zouhir, Sharif, Ghanayem, Farah, Mahagna, Fiordoro, Sukkar, Bragazzi and Mahroum. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Adawi, Mohammad
Watad, Abdulla
Brown, Stav
Aazza, Khadija
Aazza, Hicham
Zouhir, Mohamed
Sharif, Kassem
Ghanayem, Khaled
Farah, Raymond
Mahagna, Hussein
Fiordoro, Stefano
Sukkar, Samir Giuseppe
Bragazzi, Nicola Luigi
Mahroum, Naim
Ramadan Fasting Exerts Immunomodulatory Effects: Insights from a Systematic Review
title Ramadan Fasting Exerts Immunomodulatory Effects: Insights from a Systematic Review
title_full Ramadan Fasting Exerts Immunomodulatory Effects: Insights from a Systematic Review
title_fullStr Ramadan Fasting Exerts Immunomodulatory Effects: Insights from a Systematic Review
title_full_unstemmed Ramadan Fasting Exerts Immunomodulatory Effects: Insights from a Systematic Review
title_short Ramadan Fasting Exerts Immunomodulatory Effects: Insights from a Systematic Review
title_sort ramadan fasting exerts immunomodulatory effects: insights from a systematic review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712070/
https://www.ncbi.nlm.nih.gov/pubmed/29230208
http://dx.doi.org/10.3389/fimmu.2017.01144
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