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Frail phenotype is associated with distinct quantitative electroencephalographic findings among end-stage renal disease patients: an observational study

BACKGROUND: Frailty is prevalent among patients with end-stage renal disease (ESRD) and is associated with an increased risk of cognitive impairment. However, apart from its influence on cognition, it is currently unknown whether frailty affects subtler cerebral function in patients with ESRD. METHO...

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Autores principales: Chao, Chia-Ter, Lai, Hsin-Jung, Tsai, Hung-Bin, Yang, Shao-Yo, Huang, Jenq-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712101/
https://www.ncbi.nlm.nih.gov/pubmed/29197341
http://dx.doi.org/10.1186/s12877-017-0673-3
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author Chao, Chia-Ter
Lai, Hsin-Jung
Tsai, Hung-Bin
Yang, Shao-Yo
Huang, Jenq-Wen
author_facet Chao, Chia-Ter
Lai, Hsin-Jung
Tsai, Hung-Bin
Yang, Shao-Yo
Huang, Jenq-Wen
author_sort Chao, Chia-Ter
collection PubMed
description BACKGROUND: Frailty is prevalent among patients with end-stage renal disease (ESRD) and is associated with an increased risk of cognitive impairment. However, apart from its influence on cognition, it is currently unknown whether frailty affects subtler cerebral function in patients with ESRD. METHODS: Patients with ESRD were prospectively enrolled, with clinical features and laboratory data recorded. The severity of frailty among these patients with ESRD was ascertained using the previously validated simple FRAIL scale, and was categorized as none-to-mild and moderate-to-severe frailty. All participants underwent quantitative electroencephalography (EEG), with band powers documented following the generation of the delta to alpha ratio (DAR) and delta/theta to alpha/beta ratio (DTABR). EEG results were then compared between groups of different levels of frailty. RESULTS: In this cohort, (mean age: 68.9 ± 10.4 years, 37% male, 3.4 ± 3 years of dialysis), 20, 60, 40, 17, and 6% patients exhibited positivity in the fatigue, resistance, ambulation, illness, and loss-of-body-weight domains, respectively, with 45.7% being none to mildly frail and 54.3% being moderately to severely frail. Those with mild frailty had a significantly higher delta power compared to those with more severe frailty, involving all topographic sites. Patients with ESRD and severe frailty had significantly lower global, left frontal, left temporo-occipital, and right temporo-occipital DAR and DTABR, except in the right frontal area, and tended to have central accentuation of alpha, beta, and theta power, and more homogeneous DTABR and DAR distribution compared to the findings in those with mild frailty. CONCLUSIONS: Frailty in patients with ESRD can have subtler neurophysiological influences, presenting as altered EEG findings, which warrant our attention.
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spelling pubmed-57121012017-12-06 Frail phenotype is associated with distinct quantitative electroencephalographic findings among end-stage renal disease patients: an observational study Chao, Chia-Ter Lai, Hsin-Jung Tsai, Hung-Bin Yang, Shao-Yo Huang, Jenq-Wen BMC Geriatr Research Article BACKGROUND: Frailty is prevalent among patients with end-stage renal disease (ESRD) and is associated with an increased risk of cognitive impairment. However, apart from its influence on cognition, it is currently unknown whether frailty affects subtler cerebral function in patients with ESRD. METHODS: Patients with ESRD were prospectively enrolled, with clinical features and laboratory data recorded. The severity of frailty among these patients with ESRD was ascertained using the previously validated simple FRAIL scale, and was categorized as none-to-mild and moderate-to-severe frailty. All participants underwent quantitative electroencephalography (EEG), with band powers documented following the generation of the delta to alpha ratio (DAR) and delta/theta to alpha/beta ratio (DTABR). EEG results were then compared between groups of different levels of frailty. RESULTS: In this cohort, (mean age: 68.9 ± 10.4 years, 37% male, 3.4 ± 3 years of dialysis), 20, 60, 40, 17, and 6% patients exhibited positivity in the fatigue, resistance, ambulation, illness, and loss-of-body-weight domains, respectively, with 45.7% being none to mildly frail and 54.3% being moderately to severely frail. Those with mild frailty had a significantly higher delta power compared to those with more severe frailty, involving all topographic sites. Patients with ESRD and severe frailty had significantly lower global, left frontal, left temporo-occipital, and right temporo-occipital DAR and DTABR, except in the right frontal area, and tended to have central accentuation of alpha, beta, and theta power, and more homogeneous DTABR and DAR distribution compared to the findings in those with mild frailty. CONCLUSIONS: Frailty in patients with ESRD can have subtler neurophysiological influences, presenting as altered EEG findings, which warrant our attention. BioMed Central 2017-12-02 /pmc/articles/PMC5712101/ /pubmed/29197341 http://dx.doi.org/10.1186/s12877-017-0673-3 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Chao, Chia-Ter
Lai, Hsin-Jung
Tsai, Hung-Bin
Yang, Shao-Yo
Huang, Jenq-Wen
Frail phenotype is associated with distinct quantitative electroencephalographic findings among end-stage renal disease patients: an observational study
title Frail phenotype is associated with distinct quantitative electroencephalographic findings among end-stage renal disease patients: an observational study
title_full Frail phenotype is associated with distinct quantitative electroencephalographic findings among end-stage renal disease patients: an observational study
title_fullStr Frail phenotype is associated with distinct quantitative electroencephalographic findings among end-stage renal disease patients: an observational study
title_full_unstemmed Frail phenotype is associated with distinct quantitative electroencephalographic findings among end-stage renal disease patients: an observational study
title_short Frail phenotype is associated with distinct quantitative electroencephalographic findings among end-stage renal disease patients: an observational study
title_sort frail phenotype is associated with distinct quantitative electroencephalographic findings among end-stage renal disease patients: an observational study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712101/
https://www.ncbi.nlm.nih.gov/pubmed/29197341
http://dx.doi.org/10.1186/s12877-017-0673-3
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