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Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus

BACKGROUND: PDE4 cyclic nucleotide phosphodiesterases regulate 3′, 5′ cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression and other functions. The PDE4 isoform PDE4B1 also interacts with the DISC1 prote...

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Detalles Bibliográficos
Autores principales:	Campbell, Susan L., van Groen, Thomas, Kadish, Inga, Smoot, Lisa High Mitchell, Bolger, Graeme B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712142/ https://www.ncbi.nlm.nih.gov/pubmed/29197324 http://dx.doi.org/10.1186/s12868-017-0396-6

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