A Children's Oncology Group and TARGET Initiative Exploring the Genetic Landscape of Wilms Tumor

Genome-wide sequencing, mRNA and miRNA expression, DNA copy number and methylation analyses were performed on 117 Wilms tumors, followed by targeted sequencing of 651 Wilms tumors. In addition to genes previously implicated in Wilms tumors (WT1, CTNNB1, FAM123B, DROSHA, DGCR8, XPO5, DICER1, SIX1, SI...

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Autores principales: Gadd, Samantha, Huff, Vicki, Walz, Amy L., Ooms, Ariadne H.A.G., Armstrong, Amy E., Gerhard, Daniela S., Smith, Malcolm A., Guidry Auvil, Jaime M., Meerzaman, Daoud, Chen, Qing-Rong, Hsu, Chih Hao, Yan, Chunhua, Nguyen, Cu, Hu, Ying, Hermida, Leandro C., Davidsen, Tanja, Gesuwan, Patee, Ma, Yussanne, Zong, Zusheng, Mungall, Andrew J., Moore, Richard A., Marra, Marco A., Dome, Jeffrey S., Mullighan, Charles G., Ma, Jing, Wheeler, David A., Hampton, Oliver A., Ross, Nicole, Gastier-Foster, Julie M., Arold, Stefan T., Perlman, Elizabeth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712232/
https://www.ncbi.nlm.nih.gov/pubmed/28825729
http://dx.doi.org/10.1038/ng.3940
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author Gadd, Samantha
Huff, Vicki
Walz, Amy L.
Ooms, Ariadne H.A.G.
Armstrong, Amy E.
Gerhard, Daniela S.
Smith, Malcolm A.
Guidry Auvil, Jaime M.
Meerzaman, Daoud
Chen, Qing-Rong
Hsu, Chih Hao
Yan, Chunhua
Nguyen, Cu
Hu, Ying
Hermida, Leandro C.
Davidsen, Tanja
Gesuwan, Patee
Ma, Yussanne
Zong, Zusheng
Mungall, Andrew J.
Moore, Richard A.
Marra, Marco A.
Dome, Jeffrey S.
Mullighan, Charles G.
Ma, Jing
Wheeler, David A.
Hampton, Oliver A.
Ross, Nicole
Gastier-Foster, Julie M.
Arold, Stefan T.
Perlman, Elizabeth J.
author_facet Gadd, Samantha
Huff, Vicki
Walz, Amy L.
Ooms, Ariadne H.A.G.
Armstrong, Amy E.
Gerhard, Daniela S.
Smith, Malcolm A.
Guidry Auvil, Jaime M.
Meerzaman, Daoud
Chen, Qing-Rong
Hsu, Chih Hao
Yan, Chunhua
Nguyen, Cu
Hu, Ying
Hermida, Leandro C.
Davidsen, Tanja
Gesuwan, Patee
Ma, Yussanne
Zong, Zusheng
Mungall, Andrew J.
Moore, Richard A.
Marra, Marco A.
Dome, Jeffrey S.
Mullighan, Charles G.
Ma, Jing
Wheeler, David A.
Hampton, Oliver A.
Ross, Nicole
Gastier-Foster, Julie M.
Arold, Stefan T.
Perlman, Elizabeth J.
author_sort Gadd, Samantha
collection PubMed
description Genome-wide sequencing, mRNA and miRNA expression, DNA copy number and methylation analyses were performed on 117 Wilms tumors, followed by targeted sequencing of 651 Wilms tumors. In addition to genes previously implicated in Wilms tumors (WT1, CTNNB1, FAM123B, DROSHA, DGCR8, XPO5, DICER1, SIX1, SIX2, MLLT1, MYCN, and TP53), mutations were identified in genes not previously recognized as recurrently involved in Wilms tumors, the most frequent being BCOR, BCORL1, NONO, MAX, COL6A3, ASXL1, MAP3K4, and ARID1A. DNA copy number changes resulted in recurrent 1q gain, MYCN amplification, LIN28B gain, and let-7a loss. Unexpected germline variants involved PALB2 and CHEK2. Integrated analyses support two major classes of genetic changes that preserve the progenitor state and/or interrupt normal development.
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spelling pubmed-57122322018-02-21 A Children's Oncology Group and TARGET Initiative Exploring the Genetic Landscape of Wilms Tumor Gadd, Samantha Huff, Vicki Walz, Amy L. Ooms, Ariadne H.A.G. Armstrong, Amy E. Gerhard, Daniela S. Smith, Malcolm A. Guidry Auvil, Jaime M. Meerzaman, Daoud Chen, Qing-Rong Hsu, Chih Hao Yan, Chunhua Nguyen, Cu Hu, Ying Hermida, Leandro C. Davidsen, Tanja Gesuwan, Patee Ma, Yussanne Zong, Zusheng Mungall, Andrew J. Moore, Richard A. Marra, Marco A. Dome, Jeffrey S. Mullighan, Charles G. Ma, Jing Wheeler, David A. Hampton, Oliver A. Ross, Nicole Gastier-Foster, Julie M. Arold, Stefan T. Perlman, Elizabeth J. Nat Genet Article Genome-wide sequencing, mRNA and miRNA expression, DNA copy number and methylation analyses were performed on 117 Wilms tumors, followed by targeted sequencing of 651 Wilms tumors. In addition to genes previously implicated in Wilms tumors (WT1, CTNNB1, FAM123B, DROSHA, DGCR8, XPO5, DICER1, SIX1, SIX2, MLLT1, MYCN, and TP53), mutations were identified in genes not previously recognized as recurrently involved in Wilms tumors, the most frequent being BCOR, BCORL1, NONO, MAX, COL6A3, ASXL1, MAP3K4, and ARID1A. DNA copy number changes resulted in recurrent 1q gain, MYCN amplification, LIN28B gain, and let-7a loss. Unexpected germline variants involved PALB2 and CHEK2. Integrated analyses support two major classes of genetic changes that preserve the progenitor state and/or interrupt normal development. 2017-08-21 2017-10 /pmc/articles/PMC5712232/ /pubmed/28825729 http://dx.doi.org/10.1038/ng.3940 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Gadd, Samantha
Huff, Vicki
Walz, Amy L.
Ooms, Ariadne H.A.G.
Armstrong, Amy E.
Gerhard, Daniela S.
Smith, Malcolm A.
Guidry Auvil, Jaime M.
Meerzaman, Daoud
Chen, Qing-Rong
Hsu, Chih Hao
Yan, Chunhua
Nguyen, Cu
Hu, Ying
Hermida, Leandro C.
Davidsen, Tanja
Gesuwan, Patee
Ma, Yussanne
Zong, Zusheng
Mungall, Andrew J.
Moore, Richard A.
Marra, Marco A.
Dome, Jeffrey S.
Mullighan, Charles G.
Ma, Jing
Wheeler, David A.
Hampton, Oliver A.
Ross, Nicole
Gastier-Foster, Julie M.
Arold, Stefan T.
Perlman, Elizabeth J.
A Children's Oncology Group and TARGET Initiative Exploring the Genetic Landscape of Wilms Tumor
title A Children's Oncology Group and TARGET Initiative Exploring the Genetic Landscape of Wilms Tumor
title_full A Children's Oncology Group and TARGET Initiative Exploring the Genetic Landscape of Wilms Tumor
title_fullStr A Children's Oncology Group and TARGET Initiative Exploring the Genetic Landscape of Wilms Tumor
title_full_unstemmed A Children's Oncology Group and TARGET Initiative Exploring the Genetic Landscape of Wilms Tumor
title_short A Children's Oncology Group and TARGET Initiative Exploring the Genetic Landscape of Wilms Tumor
title_sort children's oncology group and target initiative exploring the genetic landscape of wilms tumor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712232/
https://www.ncbi.nlm.nih.gov/pubmed/28825729
http://dx.doi.org/10.1038/ng.3940
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