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Effects of zinc supplementation on catch-up growth in children with failure to thrive

BACKGROUND/OBJECTIVES: Although globally the numbers of children diagnosed with failure to thrive (FTT) have decreased, FTT is still a serious pediatric problem. We aimed to investigate the effects of zinc supplementation for 6 months on growth parameters of infants and children with FTT. SUBJECTS/M...

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Autores principales: Park, Seul-Gi, Choi, Ha-Neul, Yang, Hye-Ran, Yim, Jung-Eun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Nutrition Society and the Korean Society of Community Nutrition 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712499/
https://www.ncbi.nlm.nih.gov/pubmed/29209459
http://dx.doi.org/10.4162/nrp.2017.11.6.487
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author Park, Seul-Gi
Choi, Ha-Neul
Yang, Hye-Ran
Yim, Jung-Eun
author_facet Park, Seul-Gi
Choi, Ha-Neul
Yang, Hye-Ran
Yim, Jung-Eun
author_sort Park, Seul-Gi
collection PubMed
description BACKGROUND/OBJECTIVES: Although globally the numbers of children diagnosed with failure to thrive (FTT) have decreased, FTT is still a serious pediatric problem. We aimed to investigate the effects of zinc supplementation for 6 months on growth parameters of infants and children with FTT. SUBJECTS/METHODS: In this retrospective study, of the 114 participants aged between 4 months and 6 years, 89 were included in the zinc supplementation group and were provided with nutrition counseling plus an oral zinc supplement for 6 months. The caregivers of the 25 participants in the control group received nutrition counseling alone. Medical data of these children, including sex, age, height, weight, serum zinc level, and serum insulin-like growth factor 1 (IGF1) level were analyzed. RESULTS: Zinc supplementation for 6 months increased weight-for-age Z-score and serum zinc levels (5.5%) in the zinc supplementation group of underweight category children. As for stunting category, height-for-age Z-score of the participants in the zinc supplementation group increased when compared with the baseline, and serum zinc levels increased in the normal or mild stunting group. Serum IGF1 levels did not change significantly in any group. Thus, zinc supplementation was more effective in children in the underweight category than those in the stunted category; this effect differed according to the degree of the FTT. CONCLUSION: These findings suggest that zinc supplementation may have beneficial effects for growth of infants and children with FTT, and zinc supplementation would be required according to degree of FTT.
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spelling pubmed-57124992017-12-05 Effects of zinc supplementation on catch-up growth in children with failure to thrive Park, Seul-Gi Choi, Ha-Neul Yang, Hye-Ran Yim, Jung-Eun Nutr Res Pract Original Research BACKGROUND/OBJECTIVES: Although globally the numbers of children diagnosed with failure to thrive (FTT) have decreased, FTT is still a serious pediatric problem. We aimed to investigate the effects of zinc supplementation for 6 months on growth parameters of infants and children with FTT. SUBJECTS/METHODS: In this retrospective study, of the 114 participants aged between 4 months and 6 years, 89 were included in the zinc supplementation group and were provided with nutrition counseling plus an oral zinc supplement for 6 months. The caregivers of the 25 participants in the control group received nutrition counseling alone. Medical data of these children, including sex, age, height, weight, serum zinc level, and serum insulin-like growth factor 1 (IGF1) level were analyzed. RESULTS: Zinc supplementation for 6 months increased weight-for-age Z-score and serum zinc levels (5.5%) in the zinc supplementation group of underweight category children. As for stunting category, height-for-age Z-score of the participants in the zinc supplementation group increased when compared with the baseline, and serum zinc levels increased in the normal or mild stunting group. Serum IGF1 levels did not change significantly in any group. Thus, zinc supplementation was more effective in children in the underweight category than those in the stunted category; this effect differed according to the degree of the FTT. CONCLUSION: These findings suggest that zinc supplementation may have beneficial effects for growth of infants and children with FTT, and zinc supplementation would be required according to degree of FTT. The Korean Nutrition Society and the Korean Society of Community Nutrition 2017-12 2017-11-25 /pmc/articles/PMC5712499/ /pubmed/29209459 http://dx.doi.org/10.4162/nrp.2017.11.6.487 Text en ©2017 The Korean Nutrition Society and the Korean Society of Community Nutrition http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Park, Seul-Gi
Choi, Ha-Neul
Yang, Hye-Ran
Yim, Jung-Eun
Effects of zinc supplementation on catch-up growth in children with failure to thrive
title Effects of zinc supplementation on catch-up growth in children with failure to thrive
title_full Effects of zinc supplementation on catch-up growth in children with failure to thrive
title_fullStr Effects of zinc supplementation on catch-up growth in children with failure to thrive
title_full_unstemmed Effects of zinc supplementation on catch-up growth in children with failure to thrive
title_short Effects of zinc supplementation on catch-up growth in children with failure to thrive
title_sort effects of zinc supplementation on catch-up growth in children with failure to thrive
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712499/
https://www.ncbi.nlm.nih.gov/pubmed/29209459
http://dx.doi.org/10.4162/nrp.2017.11.6.487
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