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Phospholipase D and Its Essential Role in Cancer
The role of phospholipase D (PLD) in cancer development and management has been a major area of interest for researchers. The purpose of this mini-review is to explore PLD and its distinct role during chemotherapy including anti-apoptotic function. PLD is an enzyme that belongs to the phospholipase...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society for Molecular and Cellular Biology
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712509/ https://www.ncbi.nlm.nih.gov/pubmed/29145720 http://dx.doi.org/10.14348/molcells.2017.0241 |
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author | Cho, Ju Hwan Han, Joong-Soo |
author_facet | Cho, Ju Hwan Han, Joong-Soo |
author_sort | Cho, Ju Hwan |
collection | PubMed |
description | The role of phospholipase D (PLD) in cancer development and management has been a major area of interest for researchers. The purpose of this mini-review is to explore PLD and its distinct role during chemotherapy including anti-apoptotic function. PLD is an enzyme that belongs to the phospholipase super family and is found in a broad range of organisms such as viruses, yeast, bacteria, animals, and plants. The function and activity of PLD are widely dependent on and regulated by neurotransmitters, hormones, small monomeric GTPases, and lipids. A growing body of research has shown that PLD activity is significantly increased in cancer tissues and cells, indicating that it plays a critical role in signal transduction, cell proliferation, and anti-apoptotic processes. In addition, recent studies show that PLD is a downstream transcriptional target of proteins that contribute to inflammation and carcinogenesis such as Sp1, NFκB, TCF4, ATF-2, NFATc2, and EWS-Fli. Thus, compounds that inhibit expression or activity of PLD in cells can be potentially useful in reducing inflammation and sensitizing resistant cancers during chemotherapy. |
format | Online Article Text |
id | pubmed-5712509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Korean Society for Molecular and Cellular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-57125092017-12-12 Phospholipase D and Its Essential Role in Cancer Cho, Ju Hwan Han, Joong-Soo Mol Cells Minireview The role of phospholipase D (PLD) in cancer development and management has been a major area of interest for researchers. The purpose of this mini-review is to explore PLD and its distinct role during chemotherapy including anti-apoptotic function. PLD is an enzyme that belongs to the phospholipase super family and is found in a broad range of organisms such as viruses, yeast, bacteria, animals, and plants. The function and activity of PLD are widely dependent on and regulated by neurotransmitters, hormones, small monomeric GTPases, and lipids. A growing body of research has shown that PLD activity is significantly increased in cancer tissues and cells, indicating that it plays a critical role in signal transduction, cell proliferation, and anti-apoptotic processes. In addition, recent studies show that PLD is a downstream transcriptional target of proteins that contribute to inflammation and carcinogenesis such as Sp1, NFκB, TCF4, ATF-2, NFATc2, and EWS-Fli. Thus, compounds that inhibit expression or activity of PLD in cells can be potentially useful in reducing inflammation and sensitizing resistant cancers during chemotherapy. Korean Society for Molecular and Cellular Biology 2017-11-30 2017-11-16 /pmc/articles/PMC5712509/ /pubmed/29145720 http://dx.doi.org/10.14348/molcells.2017.0241 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/. |
spellingShingle | Minireview Cho, Ju Hwan Han, Joong-Soo Phospholipase D and Its Essential Role in Cancer |
title | Phospholipase D and Its Essential Role in Cancer |
title_full | Phospholipase D and Its Essential Role in Cancer |
title_fullStr | Phospholipase D and Its Essential Role in Cancer |
title_full_unstemmed | Phospholipase D and Its Essential Role in Cancer |
title_short | Phospholipase D and Its Essential Role in Cancer |
title_sort | phospholipase d and its essential role in cancer |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712509/ https://www.ncbi.nlm.nih.gov/pubmed/29145720 http://dx.doi.org/10.14348/molcells.2017.0241 |
work_keys_str_mv | AT chojuhwan phospholipasedanditsessentialroleincancer AT hanjoongsoo phospholipasedanditsessentialroleincancer |