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Phospholipase D and Its Essential Role in Cancer

The role of phospholipase D (PLD) in cancer development and management has been a major area of interest for researchers. The purpose of this mini-review is to explore PLD and its distinct role during chemotherapy including anti-apoptotic function. PLD is an enzyme that belongs to the phospholipase...

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Autores principales: Cho, Ju Hwan, Han, Joong-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712509/
https://www.ncbi.nlm.nih.gov/pubmed/29145720
http://dx.doi.org/10.14348/molcells.2017.0241
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author Cho, Ju Hwan
Han, Joong-Soo
author_facet Cho, Ju Hwan
Han, Joong-Soo
author_sort Cho, Ju Hwan
collection PubMed
description The role of phospholipase D (PLD) in cancer development and management has been a major area of interest for researchers. The purpose of this mini-review is to explore PLD and its distinct role during chemotherapy including anti-apoptotic function. PLD is an enzyme that belongs to the phospholipase super family and is found in a broad range of organisms such as viruses, yeast, bacteria, animals, and plants. The function and activity of PLD are widely dependent on and regulated by neurotransmitters, hormones, small monomeric GTPases, and lipids. A growing body of research has shown that PLD activity is significantly increased in cancer tissues and cells, indicating that it plays a critical role in signal transduction, cell proliferation, and anti-apoptotic processes. In addition, recent studies show that PLD is a downstream transcriptional target of proteins that contribute to inflammation and carcinogenesis such as Sp1, NFκB, TCF4, ATF-2, NFATc2, and EWS-Fli. Thus, compounds that inhibit expression or activity of PLD in cells can be potentially useful in reducing inflammation and sensitizing resistant cancers during chemotherapy.
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spelling pubmed-57125092017-12-12 Phospholipase D and Its Essential Role in Cancer Cho, Ju Hwan Han, Joong-Soo Mol Cells Minireview The role of phospholipase D (PLD) in cancer development and management has been a major area of interest for researchers. The purpose of this mini-review is to explore PLD and its distinct role during chemotherapy including anti-apoptotic function. PLD is an enzyme that belongs to the phospholipase super family and is found in a broad range of organisms such as viruses, yeast, bacteria, animals, and plants. The function and activity of PLD are widely dependent on and regulated by neurotransmitters, hormones, small monomeric GTPases, and lipids. A growing body of research has shown that PLD activity is significantly increased in cancer tissues and cells, indicating that it plays a critical role in signal transduction, cell proliferation, and anti-apoptotic processes. In addition, recent studies show that PLD is a downstream transcriptional target of proteins that contribute to inflammation and carcinogenesis such as Sp1, NFκB, TCF4, ATF-2, NFATc2, and EWS-Fli. Thus, compounds that inhibit expression or activity of PLD in cells can be potentially useful in reducing inflammation and sensitizing resistant cancers during chemotherapy. Korean Society for Molecular and Cellular Biology 2017-11-30 2017-11-16 /pmc/articles/PMC5712509/ /pubmed/29145720 http://dx.doi.org/10.14348/molcells.2017.0241 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.
spellingShingle Minireview
Cho, Ju Hwan
Han, Joong-Soo
Phospholipase D and Its Essential Role in Cancer
title Phospholipase D and Its Essential Role in Cancer
title_full Phospholipase D and Its Essential Role in Cancer
title_fullStr Phospholipase D and Its Essential Role in Cancer
title_full_unstemmed Phospholipase D and Its Essential Role in Cancer
title_short Phospholipase D and Its Essential Role in Cancer
title_sort phospholipase d and its essential role in cancer
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712509/
https://www.ncbi.nlm.nih.gov/pubmed/29145720
http://dx.doi.org/10.14348/molcells.2017.0241
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