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Targeted Base Editing via RNA-Guided Cytidine Deaminases in Xenopus laevis Embryos

Genome editing using programmable nucleases such as CRISPR/Cas9 or Cpf1 has emerged as powerful tools for gene knock-out or knock-in in various organisms. While most genetic diseases are caused by point mutations, these genome-editing approaches are inefficient in inducing single-nucleotide substitu...

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Detalles Bibliográficos
Autores principales:	Park, Dong-Seok, Yoon, Mijung, Kweon, Jiyeon, Jang, An-Hee, Kim, Yongsub, Choi, Sun-Cheol
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Molecular and Cellular Biology 2017
Materias:	Rapid Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712511/ https://www.ncbi.nlm.nih.gov/pubmed/29179261 http://dx.doi.org/10.14348/molcells.2017.0262

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