Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies

Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) contributes to endosomal and lysosomal function. LIMP-2 deficiency is associated with neurological abnormalities and kidney failure and, as an acid glucocerebrosidase receptor, impacts Gaucher and Parkinson’s diseases. Here we report a crystal st...

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Detalles Bibliográficos
Autores principales: Conrad, Karen S., Cheng, Ting-Wen, Ysselstein, Daniel, Heybrock, Saskia, Hoth, Lise R., Chrunyk, Boris A., am Ende, Christopher W., Krainc, Dimitri, Schwake, Michael, Saftig, Paul, Liu, Shenping, Qiu, Xiayang, Ehlers, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712522/
https://www.ncbi.nlm.nih.gov/pubmed/29199275
http://dx.doi.org/10.1038/s41467-017-02044-8

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