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The Effects of rTMS Combined with Motor Training on Functional Connectivity in Alpha Frequency Band

It has recently been reported that repetitive transcranial magnetic stimulation combined with motor training (rTMS-MT) could improve motor function in post-stroke patients. However, the effects of rTMS-MT on cortical function using functional connectivity and graph theoretical analysis remain unclea...

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Autores principales: Jin, Jing-Na, Wang, Xin, Li, Ying, Jin, Fang, Liu, Zhi-Peng, Yin, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712595/
https://www.ncbi.nlm.nih.gov/pubmed/29238296
http://dx.doi.org/10.3389/fnbeh.2017.00234
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author Jin, Jing-Na
Wang, Xin
Li, Ying
Jin, Fang
Liu, Zhi-Peng
Yin, Tao
author_facet Jin, Jing-Na
Wang, Xin
Li, Ying
Jin, Fang
Liu, Zhi-Peng
Yin, Tao
author_sort Jin, Jing-Na
collection PubMed
description It has recently been reported that repetitive transcranial magnetic stimulation combined with motor training (rTMS-MT) could improve motor function in post-stroke patients. However, the effects of rTMS-MT on cortical function using functional connectivity and graph theoretical analysis remain unclear. Ten healthy subjects were recruited to receive rTMS immediately before application of MT. Low frequency rTMS was delivered to the dominant hemisphere and non-dominant hand performed MT over 14 days. The reaction time of Nine-Hole Peg Test and electroencephalography (EEG) in resting condition with eyes closed were recorded before and after rTMS-MT. Functional connectivity was assessed by phase synchronization index (PSI), and subsequently thresholded to construct undirected graphs in alpha frequency band (8–13 Hz). We found a significant decrease in reaction time after rTMS-MT. The functional connectivity between the parietal and frontal cortex, and the graph theory statistics of node degree and efficiency in the parietal cortex increased. Besides the functional connectivity between premotor and frontal cortex, the degree and efficiency of premotor cortex showed opposite results. In addition, the number of connections significantly increased within inter-hemispheres and inter-regions. In conclusion, this study could be helpful in our understanding of how rTMS-MT modulates brain activity. The methods and results in this study could be taken as reference in future studies of the effects of rTMS-MT in stroke patients.
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spelling pubmed-57125952017-12-13 The Effects of rTMS Combined with Motor Training on Functional Connectivity in Alpha Frequency Band Jin, Jing-Na Wang, Xin Li, Ying Jin, Fang Liu, Zhi-Peng Yin, Tao Front Behav Neurosci Neuroscience It has recently been reported that repetitive transcranial magnetic stimulation combined with motor training (rTMS-MT) could improve motor function in post-stroke patients. However, the effects of rTMS-MT on cortical function using functional connectivity and graph theoretical analysis remain unclear. Ten healthy subjects were recruited to receive rTMS immediately before application of MT. Low frequency rTMS was delivered to the dominant hemisphere and non-dominant hand performed MT over 14 days. The reaction time of Nine-Hole Peg Test and electroencephalography (EEG) in resting condition with eyes closed were recorded before and after rTMS-MT. Functional connectivity was assessed by phase synchronization index (PSI), and subsequently thresholded to construct undirected graphs in alpha frequency band (8–13 Hz). We found a significant decrease in reaction time after rTMS-MT. The functional connectivity between the parietal and frontal cortex, and the graph theory statistics of node degree and efficiency in the parietal cortex increased. Besides the functional connectivity between premotor and frontal cortex, the degree and efficiency of premotor cortex showed opposite results. In addition, the number of connections significantly increased within inter-hemispheres and inter-regions. In conclusion, this study could be helpful in our understanding of how rTMS-MT modulates brain activity. The methods and results in this study could be taken as reference in future studies of the effects of rTMS-MT in stroke patients. Frontiers Media S.A. 2017-11-29 /pmc/articles/PMC5712595/ /pubmed/29238296 http://dx.doi.org/10.3389/fnbeh.2017.00234 Text en Copyright © 2017 Jin, Wang, Li, Jin, Liu and Yin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Jin, Jing-Na
Wang, Xin
Li, Ying
Jin, Fang
Liu, Zhi-Peng
Yin, Tao
The Effects of rTMS Combined with Motor Training on Functional Connectivity in Alpha Frequency Band
title The Effects of rTMS Combined with Motor Training on Functional Connectivity in Alpha Frequency Band
title_full The Effects of rTMS Combined with Motor Training on Functional Connectivity in Alpha Frequency Band
title_fullStr The Effects of rTMS Combined with Motor Training on Functional Connectivity in Alpha Frequency Band
title_full_unstemmed The Effects of rTMS Combined with Motor Training on Functional Connectivity in Alpha Frequency Band
title_short The Effects of rTMS Combined with Motor Training on Functional Connectivity in Alpha Frequency Band
title_sort effects of rtms combined with motor training on functional connectivity in alpha frequency band
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712595/
https://www.ncbi.nlm.nih.gov/pubmed/29238296
http://dx.doi.org/10.3389/fnbeh.2017.00234
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