Cargando…

Tetracycline as local drug delivery in treatment of chronic periodontitis: A systematic review and meta-analysis

BACKGROUND: The aim of the present meta-analysis is to determine the efficacy of tetracycline group of antibiotics as local drug delivery agents in the treatment of chronic periodontitis. MATERIALS AND METHODS: MEDLINE, EBSCO, Cochrane database, and Google Scholar were used to identify studies in En...

Descripción completa

Detalles Bibliográficos
Autores principales: Nadig, Prasad Shyamrajan, Shah, Monali Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713079/
https://www.ncbi.nlm.nih.gov/pubmed/29238136
http://dx.doi.org/10.4103/jisp.jisp_97_17
_version_ 1783283341975355392
author Nadig, Prasad Shyamrajan
Shah, Monali Amit
author_facet Nadig, Prasad Shyamrajan
Shah, Monali Amit
author_sort Nadig, Prasad Shyamrajan
collection PubMed
description BACKGROUND: The aim of the present meta-analysis is to determine the efficacy of tetracycline group of antibiotics as local drug delivery agents in the treatment of chronic periodontitis. MATERIALS AND METHODS: MEDLINE, EBSCO, Cochrane database, and Google Scholar were used to identify studies in English published up to January 31, 2017. An additional hand search of relevant journals and of the bibliographies of the paper identified was also performed. Articles retrieved were screened using specific inclusion criteria by two independent reviewers. Randomized control trials investigating the effect of tetracycline group of antibiotics as local drug delivery agents in chronic periodontitis were included in the study. RESULTS: Ten relevant articles were selected for the meta-analysis, of which five articles were retrieved after electronic search, three articles were included after hand search, and two unpublished articles were included. The number of patients in studies ranged from 13 to 140 sites with mean age ranging from 20 to 75. A total of 588 sites were treated using tetracycline group of antibiotics as local drug delivery agents in the treatment of chronic periodontitis. The meta-analysis showed standard difference in mean −1.02 mm (95% confidence interval [CI] 0.28, 1.75) for clinical gain in attachment in favor of tetracycline group. Standard difference in mean for probing depth (PD) was 1.20 mm (95% CI 0.57, 1.87) in tetracycline group. CONCLUSION: The results of this meta-analysis showed a significant improvement in periodontal parameters such as CAL, PD, and sulcular bleeding index in favor of tetracycline as local drug delivery compared to placebo.
format Online
Article
Text
id pubmed-5713079
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-57130792017-12-13 Tetracycline as local drug delivery in treatment of chronic periodontitis: A systematic review and meta-analysis Nadig, Prasad Shyamrajan Shah, Monali Amit J Indian Soc Periodontol Review Article BACKGROUND: The aim of the present meta-analysis is to determine the efficacy of tetracycline group of antibiotics as local drug delivery agents in the treatment of chronic periodontitis. MATERIALS AND METHODS: MEDLINE, EBSCO, Cochrane database, and Google Scholar were used to identify studies in English published up to January 31, 2017. An additional hand search of relevant journals and of the bibliographies of the paper identified was also performed. Articles retrieved were screened using specific inclusion criteria by two independent reviewers. Randomized control trials investigating the effect of tetracycline group of antibiotics as local drug delivery agents in chronic periodontitis were included in the study. RESULTS: Ten relevant articles were selected for the meta-analysis, of which five articles were retrieved after electronic search, three articles were included after hand search, and two unpublished articles were included. The number of patients in studies ranged from 13 to 140 sites with mean age ranging from 20 to 75. A total of 588 sites were treated using tetracycline group of antibiotics as local drug delivery agents in the treatment of chronic periodontitis. The meta-analysis showed standard difference in mean −1.02 mm (95% confidence interval [CI] 0.28, 1.75) for clinical gain in attachment in favor of tetracycline group. Standard difference in mean for probing depth (PD) was 1.20 mm (95% CI 0.57, 1.87) in tetracycline group. CONCLUSION: The results of this meta-analysis showed a significant improvement in periodontal parameters such as CAL, PD, and sulcular bleeding index in favor of tetracycline as local drug delivery compared to placebo. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5713079/ /pubmed/29238136 http://dx.doi.org/10.4103/jisp.jisp_97_17 Text en Copyright: © 2017 Indian Society of Periodontology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Review Article
Nadig, Prasad Shyamrajan
Shah, Monali Amit
Tetracycline as local drug delivery in treatment of chronic periodontitis: A systematic review and meta-analysis
title Tetracycline as local drug delivery in treatment of chronic periodontitis: A systematic review and meta-analysis
title_full Tetracycline as local drug delivery in treatment of chronic periodontitis: A systematic review and meta-analysis
title_fullStr Tetracycline as local drug delivery in treatment of chronic periodontitis: A systematic review and meta-analysis
title_full_unstemmed Tetracycline as local drug delivery in treatment of chronic periodontitis: A systematic review and meta-analysis
title_short Tetracycline as local drug delivery in treatment of chronic periodontitis: A systematic review and meta-analysis
title_sort tetracycline as local drug delivery in treatment of chronic periodontitis: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713079/
https://www.ncbi.nlm.nih.gov/pubmed/29238136
http://dx.doi.org/10.4103/jisp.jisp_97_17
work_keys_str_mv AT nadigprasadshyamrajan tetracyclineaslocaldrugdeliveryintreatmentofchronicperiodontitisasystematicreviewandmetaanalysis
AT shahmonaliamit tetracyclineaslocaldrugdeliveryintreatmentofchronicperiodontitisasystematicreviewandmetaanalysis