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Phospholamban Is Downregulated by pVHL-Mediated Degradation through Oxidative Stress in Failing Heart
The E3 ubiquitin ligase, von Hippel–Lindau (VHL), regulates protein expression by polyubiquitination. Although the protein VHL (pVHL) was reported to be involved in the heart function, the underlying mechanism is unclear. Here, we show that pVHL was upregulated in hearts from two types of geneticall...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713202/ https://www.ncbi.nlm.nih.gov/pubmed/29068413 http://dx.doi.org/10.3390/ijms18112232 |