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Genome Modification Technologies and Their Applications in Avian Species

The rapid development of genome modification technology has provided many great benefits in diverse areas of research and industry. Genome modification technologies have also been actively used in a variety of research areas and fields of industry in avian species. Transgenic technologies such as le...

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Detalles Bibliográficos
Autores principales: Lee, Hong Jo, Kim, Young Min, Ono, Tamao, Han, Jae Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713215/
https://www.ncbi.nlm.nih.gov/pubmed/29072628
http://dx.doi.org/10.3390/ijms18112245
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author Lee, Hong Jo
Kim, Young Min
Ono, Tamao
Han, Jae Yong
author_facet Lee, Hong Jo
Kim, Young Min
Ono, Tamao
Han, Jae Yong
author_sort Lee, Hong Jo
collection PubMed
description The rapid development of genome modification technology has provided many great benefits in diverse areas of research and industry. Genome modification technologies have also been actively used in a variety of research areas and fields of industry in avian species. Transgenic technologies such as lentiviral systems and piggyBac transposition have been used to produce transgenic birds for diverse purposes. In recent years, newly developed programmable genome editing tools such as transcription activator-like effector nuclease (TALEN) and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (CRISPR/Cas9) have also been successfully adopted in avian systems with primordial germ cell (PGC)-mediated genome modification. These genome modification technologies are expected to be applied to practical uses beyond system development itself. The technologies could be used to enhance economic traits in poultry such as acquiring a disease resistance or producing functional proteins in eggs. Furthermore, novel avian models of human diseases or embryonic development could also be established for research purposes. In this review, we discuss diverse genome modification technologies used in avian species, and future applications of avian biotechnology.
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spelling pubmed-57132152017-12-07 Genome Modification Technologies and Their Applications in Avian Species Lee, Hong Jo Kim, Young Min Ono, Tamao Han, Jae Yong Int J Mol Sci Review The rapid development of genome modification technology has provided many great benefits in diverse areas of research and industry. Genome modification technologies have also been actively used in a variety of research areas and fields of industry in avian species. Transgenic technologies such as lentiviral systems and piggyBac transposition have been used to produce transgenic birds for diverse purposes. In recent years, newly developed programmable genome editing tools such as transcription activator-like effector nuclease (TALEN) and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (CRISPR/Cas9) have also been successfully adopted in avian systems with primordial germ cell (PGC)-mediated genome modification. These genome modification technologies are expected to be applied to practical uses beyond system development itself. The technologies could be used to enhance economic traits in poultry such as acquiring a disease resistance or producing functional proteins in eggs. Furthermore, novel avian models of human diseases or embryonic development could also be established for research purposes. In this review, we discuss diverse genome modification technologies used in avian species, and future applications of avian biotechnology. MDPI 2017-10-26 /pmc/articles/PMC5713215/ /pubmed/29072628 http://dx.doi.org/10.3390/ijms18112245 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lee, Hong Jo
Kim, Young Min
Ono, Tamao
Han, Jae Yong
Genome Modification Technologies and Their Applications in Avian Species
title Genome Modification Technologies and Their Applications in Avian Species
title_full Genome Modification Technologies and Their Applications in Avian Species
title_fullStr Genome Modification Technologies and Their Applications in Avian Species
title_full_unstemmed Genome Modification Technologies and Their Applications in Avian Species
title_short Genome Modification Technologies and Their Applications in Avian Species
title_sort genome modification technologies and their applications in avian species
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713215/
https://www.ncbi.nlm.nih.gov/pubmed/29072628
http://dx.doi.org/10.3390/ijms18112245
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