A Versatile Chemo-Enzymatic Conjugation Approach Yields Homogeneous and Highly Potent Antibody-Drug Conjugates

The therapeutic efficacy of antibodies can be successfully improved through targeted delivery of potent cytotoxic drugs in the form of antibody-drug conjugates. However, conventional conjugation strategies lead to heterogeneous conjugates with undefined stoichiometry and sites, even with considerabl...

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Detalles Bibliográficos
Autores principales: Xu, Ying, Jin, Shijie, Zhao, Wenbin, Liu, Wenhui, Ding, Ding, Zhou, Jie, Chen, Shuqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713254/
https://www.ncbi.nlm.nih.gov/pubmed/29088062
http://dx.doi.org/10.3390/ijms18112284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713254/
https://www.ncbi.nlm.nih.gov/pubmed/29088062
http://dx.doi.org/10.3390/ijms18112284

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