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A Versatile Chemo-Enzymatic Conjugation Approach Yields Homogeneous and Highly Potent Antibody-Drug Conjugates
The therapeutic efficacy of antibodies can be successfully improved through targeted delivery of potent cytotoxic drugs in the form of antibody-drug conjugates. However, conventional conjugation strategies lead to heterogeneous conjugates with undefined stoichiometry and sites, even with considerabl...
Autores principales: | Xu, Ying, Jin, Shijie, Zhao, Wenbin, Liu, Wenhui, Ding, Ding, Zhou, Jie, Chen, Shuqing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713254/ https://www.ncbi.nlm.nih.gov/pubmed/29088062 http://dx.doi.org/10.3390/ijms18112284 |
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