Cargando…

A Multi-Locus Genetic Risk Score for Primary Open-Angle Glaucoma (POAG) Variants Is Associated with POAG Risk in a Mediterranean Population: Inverse Correlations with Plasma Vitamin C and E Concentrations

Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. The genetics of POAG are complex, and population-specific effects have been reported. Although many polymorphisms associated with POAG risk have been reported, few studies have analyzed their additive effects. We investiga...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zanon-Moreno, Vicente, Ortega-Azorin, Carolina, Asensio-Marquez, Eva M., Garcia-Medina, Jose J., Pinazo-Duran, Maria D., Coltell, Oscar, Ordovas, Jose M., Corella, Dolores
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713272/ https://www.ncbi.nlm.nih.gov/pubmed/29104244 http://dx.doi.org/10.3390/ijms18112302

Ejemplares similares

Chromosome 7q31 POAG locus: ocular expression of caveolins and lack of association with POAG in a US cohort
por: Kuehn, Markus H., et al.
Publicado: (2011)

Risk Factors for Primary Open Angle Glaucoma (POAG) Progression: A Study Ruled in Torino
por: Actis, A.G., et al.
Publicado: (2016)

Polymorphisms of DNA repair genes XRCC1 and XPD and risk of primary open angle glaucoma (POAG)
por: Güven, Mehmet, et al.
Publicado: (2007)

Primary Open-Angle African American Glaucoma Genetics (POAAGG) Study: gender and risk of POAG in African Americans
por: Khachatryan, Naira, et al.
Publicado: (2019)

Myocilin mutations in black South Africans with POAG
por: Whigham, Benjamin T., et al.
Publicado: (2011)

Choroidal Microvasculature Dropout in the Absence of Parapapillary Atrophy in POAG
por: Lee, Eun Ji, et al.
Publicado: (2023)

Evaluation of the CYP1B1 gene as a candidate gene in beagles with primary open-angle glaucoma (POAG)
por: Kato, K., et al.
Publicado: (2009)

Global variations and time trends in the prevalence of primary open angle glaucoma (POAG): a systematic review and meta-analysis
por: Kapetanakis, Venediktos V, et al.
Publicado: (2016)

CDKN2B Polymorphism Is Associated with Primary Open-Angle Glaucoma (POAG) in the Afro-Caribbean Population of Barbados, West Indies
por: Cao, Dan, et al.
Publicado: (2012)

Myocilin and optineurin coding variants in Hispanics of Mexican Descent with POAG
por: McDonald, Kristin K., et al.
Publicado: (2010)

Comprehensive analysis of myocilin variants in east Indian POAG patients
por: Banerjee, Deblina, et al.
Publicado: (2012)

Effects of polymorphisms in vitamin E-, vitamin C-, and glutathione peroxidase-related genes on serum biomarkers and associations with glaucoma
por: Zanon-Moreno, Vicente, et al.
Publicado: (2013)

Mutational analysis of CYP1B1 (rs56010818) variant in primary open angle glaucoma (POAG) affected patients of Pakistan
por: Narsani, Ashok Kumar, et al.
Publicado: (2022)

The correlation between primary open-angle glaucoma (POAG) and gut microbiota: a pilot study towards predictive, preventive, and personalized medicine
por: Chen, Si, et al.
Publicado: (2023)

Intermediate outcomes of ab externo circumferential trabeculotomy and canaloplasty in POAG patients with prior incisional glaucoma surgery
por: Wang, Huaizhou, et al.
Publicado: (2020)

Association between a SLC23A2 gene variation, plasma vitamin C levels, and risk of glaucoma in a Mediterranean population
por: Zanon-Moreno, Vicente, et al.
Publicado: (2011)

The Genetics of POAG in Black South Africans: A Candidate Gene Association Study
por: Williams, Susan E. I., et al.
Publicado: (2015)

Activation of ATF4 triggers trabecular meshwork cell dysfunction and apoptosis in POAG
por: Ying, Ying, et al.
Publicado: (2021)

Cost of the medical management and prescription pattern for primary open angle glaucoma (POAG) in Ghana–a retrospective cross-sectional study from three referral facilities
por: Ocansey, Stephen, et al.
Publicado: (2016)

Genetic association between CDKN2B-AS1 polymorphisms and the susceptibility of primary open-angle glaucoma (POAG): a meta-analysis from 21,775 subjects
por: Liu, Shanshan, et al.
Publicado: (2021)

Upregulation of Copine1 in trabecular meshwork cells of POAG patients: a membrane proteomics approach
por: Zhang, Yuehong, et al.
Publicado: (2008)

Ocular Expression and Distribution of Products of the POAG-Associated Chromosome 9p21 Gene Region
por: Chidlow, Glyn, et al.
Publicado: (2013)

Association of the SNP rs112369934 near TRIM66 Gene with POAG Endophenotypes in African Americans
por: Kim, Claire D., et al.
Publicado: (2021)

Candidate Gene and Genome-Wide Association Studies for Circulating Leptin Levels Reveal Population and Sex-Specific Associations in High Cardiovascular Risk Mediterranean Subjects
por: Ortega-Azorín, Carolina, et al.
Publicado: (2019)

Smoking, an additional risk factor in elder women with primary open-angle glaucoma
por: Zanon-Moreno, Vicente, et al.
Publicado: (2009)

Plexin domain containing 2 (PLXDC2) gene polymorphism rs7081455 may not influence POAG risk in a Saudi cohort
por: Kondkar, Altaf A., et al.
Publicado: (2018)

Influence of Demographic and Lifestyle Variables on Plasma Magnesium Concentrations and Their Associations with Cardiovascular Risk Factors in a Mediterranean Population
por: Barragán, Rocío, et al.
Publicado: (2020)

Lack of association of SNP rs4236601 near CAV1 and CAV2 with POAG in a Saudi cohort
por: Abu-Amero, Khaled K., et al.
Publicado: (2012)

MTHFR C677T Predisposes to POAG but Not to PACG in a North Indian Population: A Case Control Study
por: Gupta, Shashank, et al.
Publicado: (2014)

Roles of CYP2C19 Gene Polymorphisms in Susceptibility to POAG and Individual Differences in Drug Treatment Response
por: Liu, Xiang-Long, et al.
Publicado: (2016)

AQP1 suppression by ATF4 triggers trabecular meshwork tissue remodelling in ET‐1‐induced POAG
por: Zhao, Yingying, et al.
Publicado: (2020)

SNP located in an AluJb repeat downstream of TMCO1, rs4657473, is protective for POAG in African Americans
por: Verkuil, Lana, et al.
Publicado: (2019)

Circulating Adiponectin and Its Association with Metabolic Traits and Type 2 Diabetes: Gene-Diet Interactions Focusing on Selected Gene Variants and at the Genome-Wide Level in High-Cardiovascular Risk Mediterranean Subjects
por: Coltell, Oscar, et al.
Publicado: (2021)

Associations between the New DNA-Methylation-Based Telomere Length Estimator, the Mediterranean Diet and Genetics in a Spanish Population at High Cardiovascular Risk
por: Coltell, Oscar, et al.
Publicado: (2023)

Progression to severe visual impairment and blindness in POAG patients: pace and risk factors—a cohort study using German health claims data
por: Nestler, Sophia, et al.
Publicado: (2022)

Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome
por: Coltell, Oscar, et al.
Publicado: (2020)

Myocilin mutations among POAG patients from two populations of Tamil Nadu, South India, a comparative analysis
por: Rose, Rajiv, et al.
Publicado: (2011)

Molecular Genetics and Functional Analysis Implicate CDKN2BAS1-CDKN2B Involvement in POAG Pathogenesis
por: Rathi, Sonika, et al.
Publicado: (2020)

Association between Microbiome-Related Human Genetic Variants and Fasting Plasma Glucose in a High-Cardiovascular-Risk Mediterranean Population
por: Asensio, Eva M., et al.
Publicado: (2022)

A Transcriptome-Wide Association Study of Cognitive Impairment in Subjects With Metabolic Syndrome Adjusted for Adherence to Mediterranean Diet
por: Coltell, Oscar, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_jpdcuubv4km33idjjvascto7iq