Development of 1,2,3-Triazole-Based Sphingosine Kinase Inhibitors and Their Evaluation as Antiproliferative Agents

Two series of N-(aryl)-1-(hydroxyalkyl)pyrrolidine-2-carboxamides (2a–2g and 3a–3g) and 1,4-disubstituted 1,2,3-triazoles (5a–5h and 8a–8h) were synthesized. All the compounds, containing a lipophilic tail and a polar headgroup, were evaluated as sphingosine kinase (SphK) inhibitors by assessing the...

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Detalles Bibliográficos
Autores principales: Corvino, Angela, Rosa, Roberta, Incisivo, Giuseppina Maria, Fiorino, Ferdinando, Frecentese, Francesco, Magli, Elisa, Perissutti, Elisa, Saccone, Irene, Santagada, Vincenzo, Cirino, Giuseppe, Riemma, Maria Antonietta, Temussi, Piero A., Ciciola, Paola, Bianco, Roberto, Caliendo, Giuseppe, Roviezzo, Fiorentina, Severino, Beatrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713301/
https://www.ncbi.nlm.nih.gov/pubmed/29113071
http://dx.doi.org/10.3390/ijms18112332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713301/
https://www.ncbi.nlm.nih.gov/pubmed/29113071
http://dx.doi.org/10.3390/ijms18112332

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