Cargando…
Recipient HLA-G +3142 CC Genotype and Concentrations of Soluble HLA-G Impact on Occurrence of CMV Infection after Living-Donor Kidney Transplantation
The expression modulation of the immunosuppressive non-classical Human leukocyte antigen-G (HLA-G) molecule and its soluble isoforms is an immune evasion strategy being deployed by cytomegalovirus (CMV). The +3142 C>G single nucleotide polymorphism (SNP) located within the 3′ untranslated region...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713307/ https://www.ncbi.nlm.nih.gov/pubmed/29113092 http://dx.doi.org/10.3390/ijms18112338 |
_version_ | 1783283394162982912 |
---|---|
author | Guberina, Hana Tomoya Michita, Rafael Dolff, Sebastian Bienholz, Anja Trilling, Mirko Heinemann, Falko M. Horn, Peter A. Kribben, Andreas Witzke, Oliver Rebmann, Vera |
author_facet | Guberina, Hana Tomoya Michita, Rafael Dolff, Sebastian Bienholz, Anja Trilling, Mirko Heinemann, Falko M. Horn, Peter A. Kribben, Andreas Witzke, Oliver Rebmann, Vera |
author_sort | Guberina, Hana |
collection | PubMed |
description | The expression modulation of the immunosuppressive non-classical Human leukocyte antigen-G (HLA-G) molecule and its soluble isoforms is an immune evasion strategy being deployed by cytomegalovirus (CMV). The +3142 C>G single nucleotide polymorphism (SNP) located within the 3′ untranslated region (3′UTR) is of crucial importance for the regulation of HLA-G expression. Therefore, we analyzed the influence of the +3142 C>G HLA-G SNP on the occurrence of CMV infection in a cohort of 178 living-donor kidney recipients and their 178 corresponding donors. In addition, soluble HLA-G (sHLA-G) levels were quantified before and after transplantation. The presence of the HLA-G +3142 CC genotype in recipients, but not donors of our cohort as along with elevated sHLA-G levels (≥6.1 ng/mL) were associated with higher susceptibility to CMV infection after transplantation. Our results provided evidence that (i) HLA-G is implicated in the establishment of CMV after living-donor kidney transplantation and (ii) recipient HLA-G +3142 CC genotype and sHLA-G concentration levels could represent important predictive risk markers for CMV infection. |
format | Online Article Text |
id | pubmed-5713307 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57133072017-12-07 Recipient HLA-G +3142 CC Genotype and Concentrations of Soluble HLA-G Impact on Occurrence of CMV Infection after Living-Donor Kidney Transplantation Guberina, Hana Tomoya Michita, Rafael Dolff, Sebastian Bienholz, Anja Trilling, Mirko Heinemann, Falko M. Horn, Peter A. Kribben, Andreas Witzke, Oliver Rebmann, Vera Int J Mol Sci Article The expression modulation of the immunosuppressive non-classical Human leukocyte antigen-G (HLA-G) molecule and its soluble isoforms is an immune evasion strategy being deployed by cytomegalovirus (CMV). The +3142 C>G single nucleotide polymorphism (SNP) located within the 3′ untranslated region (3′UTR) is of crucial importance for the regulation of HLA-G expression. Therefore, we analyzed the influence of the +3142 C>G HLA-G SNP on the occurrence of CMV infection in a cohort of 178 living-donor kidney recipients and their 178 corresponding donors. In addition, soluble HLA-G (sHLA-G) levels were quantified before and after transplantation. The presence of the HLA-G +3142 CC genotype in recipients, but not donors of our cohort as along with elevated sHLA-G levels (≥6.1 ng/mL) were associated with higher susceptibility to CMV infection after transplantation. Our results provided evidence that (i) HLA-G is implicated in the establishment of CMV after living-donor kidney transplantation and (ii) recipient HLA-G +3142 CC genotype and sHLA-G concentration levels could represent important predictive risk markers for CMV infection. MDPI 2017-11-05 /pmc/articles/PMC5713307/ /pubmed/29113092 http://dx.doi.org/10.3390/ijms18112338 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Guberina, Hana Tomoya Michita, Rafael Dolff, Sebastian Bienholz, Anja Trilling, Mirko Heinemann, Falko M. Horn, Peter A. Kribben, Andreas Witzke, Oliver Rebmann, Vera Recipient HLA-G +3142 CC Genotype and Concentrations of Soluble HLA-G Impact on Occurrence of CMV Infection after Living-Donor Kidney Transplantation |
title | Recipient HLA-G +3142 CC Genotype and Concentrations of Soluble HLA-G Impact on Occurrence of CMV Infection after Living-Donor Kidney Transplantation |
title_full | Recipient HLA-G +3142 CC Genotype and Concentrations of Soluble HLA-G Impact on Occurrence of CMV Infection after Living-Donor Kidney Transplantation |
title_fullStr | Recipient HLA-G +3142 CC Genotype and Concentrations of Soluble HLA-G Impact on Occurrence of CMV Infection after Living-Donor Kidney Transplantation |
title_full_unstemmed | Recipient HLA-G +3142 CC Genotype and Concentrations of Soluble HLA-G Impact on Occurrence of CMV Infection after Living-Donor Kidney Transplantation |
title_short | Recipient HLA-G +3142 CC Genotype and Concentrations of Soluble HLA-G Impact on Occurrence of CMV Infection after Living-Donor Kidney Transplantation |
title_sort | recipient hla-g +3142 cc genotype and concentrations of soluble hla-g impact on occurrence of cmv infection after living-donor kidney transplantation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713307/ https://www.ncbi.nlm.nih.gov/pubmed/29113092 http://dx.doi.org/10.3390/ijms18112338 |
work_keys_str_mv | AT guberinahana recipienthlag3142ccgenotypeandconcentrationsofsolublehlagimpactonoccurrenceofcmvinfectionafterlivingdonorkidneytransplantation AT tomoyamichitarafael recipienthlag3142ccgenotypeandconcentrationsofsolublehlagimpactonoccurrenceofcmvinfectionafterlivingdonorkidneytransplantation AT dolffsebastian recipienthlag3142ccgenotypeandconcentrationsofsolublehlagimpactonoccurrenceofcmvinfectionafterlivingdonorkidneytransplantation AT bienholzanja recipienthlag3142ccgenotypeandconcentrationsofsolublehlagimpactonoccurrenceofcmvinfectionafterlivingdonorkidneytransplantation AT trillingmirko recipienthlag3142ccgenotypeandconcentrationsofsolublehlagimpactonoccurrenceofcmvinfectionafterlivingdonorkidneytransplantation AT heinemannfalkom recipienthlag3142ccgenotypeandconcentrationsofsolublehlagimpactonoccurrenceofcmvinfectionafterlivingdonorkidneytransplantation AT hornpetera recipienthlag3142ccgenotypeandconcentrationsofsolublehlagimpactonoccurrenceofcmvinfectionafterlivingdonorkidneytransplantation AT kribbenandreas recipienthlag3142ccgenotypeandconcentrationsofsolublehlagimpactonoccurrenceofcmvinfectionafterlivingdonorkidneytransplantation AT witzkeoliver recipienthlag3142ccgenotypeandconcentrationsofsolublehlagimpactonoccurrenceofcmvinfectionafterlivingdonorkidneytransplantation AT rebmannvera recipienthlag3142ccgenotypeandconcentrationsofsolublehlagimpactonoccurrenceofcmvinfectionafterlivingdonorkidneytransplantation |