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KLF2 in Regulation of NF-κB-Mediated Immune Cell Function and Inflammation
KLF2 (Kruppel-like factor 2) is a member of the zinc finger transcription factor family, which critically regulates embryonic lung development, function of endothelial cells and maintenance of quiescence in T-cells and monocytes. It is expressed in naïve T-cells and monocytes, however its level of e...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713352/ https://www.ncbi.nlm.nih.gov/pubmed/29125549 http://dx.doi.org/10.3390/ijms18112383 |
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author | Jha, Prerana Das, Hiranmoy |
author_facet | Jha, Prerana Das, Hiranmoy |
author_sort | Jha, Prerana |
collection | PubMed |
description | KLF2 (Kruppel-like factor 2) is a member of the zinc finger transcription factor family, which critically regulates embryonic lung development, function of endothelial cells and maintenance of quiescence in T-cells and monocytes. It is expressed in naïve T-cells and monocytes, however its level of expression decreases during activation and differentiation. KLF2 also plays critical regulatory role in various inflammatory diseases and their pathogenesis. Nuclear factor-kappaB (NF-κB) is an important inducer of inflammation and the inflammation is mediated through the transcription of several proinflammatory cytokines, chemokines and adhesion molecules. So, both transcriptional factors KLF2 and NF-κB are being associated with the similar cellular functions and their maintenance. It was shown that KLF2 regulates most of the NF-κB-mediated activities. In this review, we focused on emphasizing the involvement of KLF2 in health and disease states and how they interact with transcriptional master regulator NF-κB. |
format | Online Article Text |
id | pubmed-5713352 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57133522017-12-07 KLF2 in Regulation of NF-κB-Mediated Immune Cell Function and Inflammation Jha, Prerana Das, Hiranmoy Int J Mol Sci Review KLF2 (Kruppel-like factor 2) is a member of the zinc finger transcription factor family, which critically regulates embryonic lung development, function of endothelial cells and maintenance of quiescence in T-cells and monocytes. It is expressed in naïve T-cells and monocytes, however its level of expression decreases during activation and differentiation. KLF2 also plays critical regulatory role in various inflammatory diseases and their pathogenesis. Nuclear factor-kappaB (NF-κB) is an important inducer of inflammation and the inflammation is mediated through the transcription of several proinflammatory cytokines, chemokines and adhesion molecules. So, both transcriptional factors KLF2 and NF-κB are being associated with the similar cellular functions and their maintenance. It was shown that KLF2 regulates most of the NF-κB-mediated activities. In this review, we focused on emphasizing the involvement of KLF2 in health and disease states and how they interact with transcriptional master regulator NF-κB. MDPI 2017-11-10 /pmc/articles/PMC5713352/ /pubmed/29125549 http://dx.doi.org/10.3390/ijms18112383 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jha, Prerana Das, Hiranmoy KLF2 in Regulation of NF-κB-Mediated Immune Cell Function and Inflammation |
title | KLF2 in Regulation of NF-κB-Mediated Immune Cell Function and Inflammation |
title_full | KLF2 in Regulation of NF-κB-Mediated Immune Cell Function and Inflammation |
title_fullStr | KLF2 in Regulation of NF-κB-Mediated Immune Cell Function and Inflammation |
title_full_unstemmed | KLF2 in Regulation of NF-κB-Mediated Immune Cell Function and Inflammation |
title_short | KLF2 in Regulation of NF-κB-Mediated Immune Cell Function and Inflammation |
title_sort | klf2 in regulation of nf-κb-mediated immune cell function and inflammation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713352/ https://www.ncbi.nlm.nih.gov/pubmed/29125549 http://dx.doi.org/10.3390/ijms18112383 |
work_keys_str_mv | AT jhaprerana klf2inregulationofnfkbmediatedimmunecellfunctionandinflammation AT dashiranmoy klf2inregulationofnfkbmediatedimmunecellfunctionandinflammation |