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cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response
The last two decades have witnessed enormous growth in the field of cancer immunity. Mechanistic insights of cancer immunoediting have not only enhanced our understanding but also paved the way to target and/or harness the innate immune system to combat cancer, called cancer immunotherapy. Cyclic GM...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713423/ https://www.ncbi.nlm.nih.gov/pubmed/29156566 http://dx.doi.org/10.3390/ijms18112456 |
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author | Bose, Debojit |
author_facet | Bose, Debojit |
author_sort | Bose, Debojit |
collection | PubMed |
description | The last two decades have witnessed enormous growth in the field of cancer immunity. Mechanistic insights of cancer immunoediting have not only enhanced our understanding but also paved the way to target and/or harness the innate immune system to combat cancer, called cancer immunotherapy. Cyclic GMP-AMP synthase (cGAS)/Stimulator of interferon genes(STING) pathway has recently emerged as nodal player in cancer immunity and is currently being explored as potential therapeutic target. Although therapeutic activation of this pathway has shown promising anti-tumor effects in vivo, evidence also indicates the role of this pathway in inflammation mediated carcinogenesis. This review highlights our current understanding of cGAS/STING pathway in cancer, its therapeutic targeting and potential alternate approaches to target this pathway. Optimal therapeutic targeting and artificial tunability of this pathway still demand in depth understanding of cGAS/STING pathway regulation and homeostasis. |
format | Online Article Text |
id | pubmed-5713423 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57134232017-12-07 cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response Bose, Debojit Int J Mol Sci Review The last two decades have witnessed enormous growth in the field of cancer immunity. Mechanistic insights of cancer immunoediting have not only enhanced our understanding but also paved the way to target and/or harness the innate immune system to combat cancer, called cancer immunotherapy. Cyclic GMP-AMP synthase (cGAS)/Stimulator of interferon genes(STING) pathway has recently emerged as nodal player in cancer immunity and is currently being explored as potential therapeutic target. Although therapeutic activation of this pathway has shown promising anti-tumor effects in vivo, evidence also indicates the role of this pathway in inflammation mediated carcinogenesis. This review highlights our current understanding of cGAS/STING pathway in cancer, its therapeutic targeting and potential alternate approaches to target this pathway. Optimal therapeutic targeting and artificial tunability of this pathway still demand in depth understanding of cGAS/STING pathway regulation and homeostasis. MDPI 2017-11-18 /pmc/articles/PMC5713423/ /pubmed/29156566 http://dx.doi.org/10.3390/ijms18112456 Text en © 2017 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bose, Debojit cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response |
title | cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response |
title_full | cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response |
title_fullStr | cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response |
title_full_unstemmed | cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response |
title_short | cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response |
title_sort | cgas/sting pathway in cancer: jekyll and hyde story of cancer immune response |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713423/ https://www.ncbi.nlm.nih.gov/pubmed/29156566 http://dx.doi.org/10.3390/ijms18112456 |
work_keys_str_mv | AT bosedebojit cgasstingpathwayincancerjekyllandhydestoryofcancerimmuneresponse |