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cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response

The last two decades have witnessed enormous growth in the field of cancer immunity. Mechanistic insights of cancer immunoediting have not only enhanced our understanding but also paved the way to target and/or harness the innate immune system to combat cancer, called cancer immunotherapy. Cyclic GM...

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Detalles Bibliográficos
Autor principal: Bose, Debojit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713423/
https://www.ncbi.nlm.nih.gov/pubmed/29156566
http://dx.doi.org/10.3390/ijms18112456
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author Bose, Debojit
author_facet Bose, Debojit
author_sort Bose, Debojit
collection PubMed
description The last two decades have witnessed enormous growth in the field of cancer immunity. Mechanistic insights of cancer immunoediting have not only enhanced our understanding but also paved the way to target and/or harness the innate immune system to combat cancer, called cancer immunotherapy. Cyclic GMP-AMP synthase (cGAS)/Stimulator of interferon genes(STING) pathway has recently emerged as nodal player in cancer immunity and is currently being explored as potential therapeutic target. Although therapeutic activation of this pathway has shown promising anti-tumor effects in vivo, evidence also indicates the role of this pathway in inflammation mediated carcinogenesis. This review highlights our current understanding of cGAS/STING pathway in cancer, its therapeutic targeting and potential alternate approaches to target this pathway. Optimal therapeutic targeting and artificial tunability of this pathway still demand in depth understanding of cGAS/STING pathway regulation and homeostasis.
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spelling pubmed-57134232017-12-07 cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response Bose, Debojit Int J Mol Sci Review The last two decades have witnessed enormous growth in the field of cancer immunity. Mechanistic insights of cancer immunoediting have not only enhanced our understanding but also paved the way to target and/or harness the innate immune system to combat cancer, called cancer immunotherapy. Cyclic GMP-AMP synthase (cGAS)/Stimulator of interferon genes(STING) pathway has recently emerged as nodal player in cancer immunity and is currently being explored as potential therapeutic target. Although therapeutic activation of this pathway has shown promising anti-tumor effects in vivo, evidence also indicates the role of this pathway in inflammation mediated carcinogenesis. This review highlights our current understanding of cGAS/STING pathway in cancer, its therapeutic targeting and potential alternate approaches to target this pathway. Optimal therapeutic targeting and artificial tunability of this pathway still demand in depth understanding of cGAS/STING pathway regulation and homeostasis. MDPI 2017-11-18 /pmc/articles/PMC5713423/ /pubmed/29156566 http://dx.doi.org/10.3390/ijms18112456 Text en © 2017 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bose, Debojit
cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response
title cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response
title_full cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response
title_fullStr cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response
title_full_unstemmed cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response
title_short cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response
title_sort cgas/sting pathway in cancer: jekyll and hyde story of cancer immune response
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713423/
https://www.ncbi.nlm.nih.gov/pubmed/29156566
http://dx.doi.org/10.3390/ijms18112456
work_keys_str_mv AT bosedebojit cgasstingpathwayincancerjekyllandhydestoryofcancerimmuneresponse