Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase

Two new ergostane-type sterols; (22E)-5α,6α-epoxyergosta-8,14,22-triene-3β,7β-diol (1) and 5α,6α-epoxyergost-8(14)-ene-3β,7α-diol (2) were isolated from the fruiting bodies of king trumpet mushroom (Pleurotus eryngii), along with eight known compounds (3–10). All isolated compounds were evaluated fo...

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Autores principales: Kikuchi, Takashi, Motoyashiki, Naoki, Yamada, Takeshi, Shibatani, Kanae, Ninomiya, Kiyofumi, Morikawa, Toshio, Tanaka, Reiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713445/
https://www.ncbi.nlm.nih.gov/pubmed/29160820
http://dx.doi.org/10.3390/ijms18112479
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author Kikuchi, Takashi
Motoyashiki, Naoki
Yamada, Takeshi
Shibatani, Kanae
Ninomiya, Kiyofumi
Morikawa, Toshio
Tanaka, Reiko
author_facet Kikuchi, Takashi
Motoyashiki, Naoki
Yamada, Takeshi
Shibatani, Kanae
Ninomiya, Kiyofumi
Morikawa, Toshio
Tanaka, Reiko
author_sort Kikuchi, Takashi
collection PubMed
description Two new ergostane-type sterols; (22E)-5α,6α-epoxyergosta-8,14,22-triene-3β,7β-diol (1) and 5α,6α-epoxyergost-8(14)-ene-3β,7α-diol (2) were isolated from the fruiting bodies of king trumpet mushroom (Pleurotus eryngii), along with eight known compounds (3–10). All isolated compounds were evaluated for their inhibitory effects on aromatase. Among them, 4 and 6 exhibited comparable aromatase inhibitory activities to aminoglutethimide.
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spelling pubmed-57134452017-12-07 Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase Kikuchi, Takashi Motoyashiki, Naoki Yamada, Takeshi Shibatani, Kanae Ninomiya, Kiyofumi Morikawa, Toshio Tanaka, Reiko Int J Mol Sci Article Two new ergostane-type sterols; (22E)-5α,6α-epoxyergosta-8,14,22-triene-3β,7β-diol (1) and 5α,6α-epoxyergost-8(14)-ene-3β,7α-diol (2) were isolated from the fruiting bodies of king trumpet mushroom (Pleurotus eryngii), along with eight known compounds (3–10). All isolated compounds were evaluated for their inhibitory effects on aromatase. Among them, 4 and 6 exhibited comparable aromatase inhibitory activities to aminoglutethimide. MDPI 2017-11-21 /pmc/articles/PMC5713445/ /pubmed/29160820 http://dx.doi.org/10.3390/ijms18112479 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kikuchi, Takashi
Motoyashiki, Naoki
Yamada, Takeshi
Shibatani, Kanae
Ninomiya, Kiyofumi
Morikawa, Toshio
Tanaka, Reiko
Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase
title Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase
title_full Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase
title_fullStr Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase
title_full_unstemmed Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase
title_short Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase
title_sort ergostane-type sterols from king trumpet mushroom (pleurotus eryngii) and their inhibitory effects on aromatase
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713445/
https://www.ncbi.nlm.nih.gov/pubmed/29160820
http://dx.doi.org/10.3390/ijms18112479
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