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The coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer
Non-small-cell lung cancer (NSCLC) is a common disease threatening the health of humankind. It has a low survival rate and a poor prognosis. Under normal circumstances, tumor infiltrating lymphocytes (TILs) play the main role in the antitumor process, but studies in recent years have found that NSCL...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713689/ https://www.ncbi.nlm.nih.gov/pubmed/29238163 http://dx.doi.org/10.2147/DDDT.S148443 |
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author | Guo, Wenjie Liu, Sihan Zhang, Xiaoli Chen, Yating Qian, Ruolan Zou, Ziyuan Chen, Xin Luo, Peng |
author_facet | Guo, Wenjie Liu, Sihan Zhang, Xiaoli Chen, Yating Qian, Ruolan Zou, Ziyuan Chen, Xin Luo, Peng |
author_sort | Guo, Wenjie |
collection | PubMed |
description | Non-small-cell lung cancer (NSCLC) is a common disease threatening the health of humankind. It has a low survival rate and a poor prognosis. Under normal circumstances, tumor infiltrating lymphocytes (TILs) play the main role in the antitumor process, but studies in recent years have found that NSCLC is capable of releasing various immunosuppressive factors, inducing the TILs to exhibit high expression of immune inhibitory receptors and relevant immunosuppressive factors. They can not only activate their own signal pathways but also block those of TILs, which causes inefficiency of tumor destruction. Researchers have now developed targeted drugs that specifically bind to immunosuppression receptors. By blocking signal transmission of immune inhibitory receptors, restraint on T lymphocytes can be released to recover antitumor role. Further research and understanding of the immunosuppression signal pathways of NSCLC are of significant importance to promote the development of immune-targeted drugs and the formulation of new treatment plans. This paper summarizes the immunosuppressive mechanisms of multiple important and newly discovered immune inhibitory receptors on T lymphocytes and immunosuppressive factors released by NSCLC cells, and their influence on patients’ survival rate and prognosis. Further laboratory and clinical studies on immune-targeted drugs for primary NSCLC are needed to provide more evidence. |
format | Online Article Text |
id | pubmed-5713689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-57136892017-12-13 The coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer Guo, Wenjie Liu, Sihan Zhang, Xiaoli Chen, Yating Qian, Ruolan Zou, Ziyuan Chen, Xin Luo, Peng Drug Des Devel Ther Review Non-small-cell lung cancer (NSCLC) is a common disease threatening the health of humankind. It has a low survival rate and a poor prognosis. Under normal circumstances, tumor infiltrating lymphocytes (TILs) play the main role in the antitumor process, but studies in recent years have found that NSCLC is capable of releasing various immunosuppressive factors, inducing the TILs to exhibit high expression of immune inhibitory receptors and relevant immunosuppressive factors. They can not only activate their own signal pathways but also block those of TILs, which causes inefficiency of tumor destruction. Researchers have now developed targeted drugs that specifically bind to immunosuppression receptors. By blocking signal transmission of immune inhibitory receptors, restraint on T lymphocytes can be released to recover antitumor role. Further research and understanding of the immunosuppression signal pathways of NSCLC are of significant importance to promote the development of immune-targeted drugs and the formulation of new treatment plans. This paper summarizes the immunosuppressive mechanisms of multiple important and newly discovered immune inhibitory receptors on T lymphocytes and immunosuppressive factors released by NSCLC cells, and their influence on patients’ survival rate and prognosis. Further laboratory and clinical studies on immune-targeted drugs for primary NSCLC are needed to provide more evidence. Dove Medical Press 2017-11-28 /pmc/articles/PMC5713689/ /pubmed/29238163 http://dx.doi.org/10.2147/DDDT.S148443 Text en © 2017 Guo et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Guo, Wenjie Liu, Sihan Zhang, Xiaoli Chen, Yating Qian, Ruolan Zou, Ziyuan Chen, Xin Luo, Peng The coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer |
title | The coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer |
title_full | The coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer |
title_fullStr | The coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer |
title_full_unstemmed | The coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer |
title_short | The coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer |
title_sort | coexpression of multi-immune inhibitory receptors on t lymphocytes in primary non-small-cell lung cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713689/ https://www.ncbi.nlm.nih.gov/pubmed/29238163 http://dx.doi.org/10.2147/DDDT.S148443 |
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