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A novel transdermal nanoethosomal gel of betahistine dihydrochloride for weight gain control: in-vitro and in-vivo characterization
BACKGROUND: Betahistine dihydrochloride (BDH) is a histamine analog used to control weight gain, with short elimination half-life and gastric irritation as side effects. OBJECTIVE: The aim of the current investigation is to formulate and optimize a topical BDH ethosomal gel for weight gain control....
Autores principales: | El-Menshawe, Shahira F, Ali, Adel Ahmed, Halawa, Abdelkhalk Ali, Srag El-Din, Ahmed SG |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713695/ https://www.ncbi.nlm.nih.gov/pubmed/29238164 http://dx.doi.org/10.2147/DDDT.S144652 |
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