Structural insight into the methyltransfer mechanism of the bifunctional Trm5

The wyosine derivatives present at position 37 in transfer RNAs (tRNAs) are critical for reading frame maintenance. The methyltransferase Trm5a from Pyrococcus abyssi (PaTrm5a) plays a key role in this hypermodification process in generating m(1)G37 and imG2, two products of the wyosine biosynthetic...

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Detalles Bibliográficos
Autores principales: Wang, Caiyan, Jia, Qian, Zeng, Jianhua, Chen, Ran, Xie, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714064/
https://www.ncbi.nlm.nih.gov/pubmed/29214216
http://dx.doi.org/10.1126/sciadv.1700195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714064/
https://www.ncbi.nlm.nih.gov/pubmed/29214216
http://dx.doi.org/10.1126/sciadv.1700195

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