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Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation

Eukaryotic translation initiation factor 2 (eIF2) is a heterotrimeric GTPase, which plays a critical role in protein synthesis regulation. eIF2-GTP binds Met-tRNA(i) to form the eIF2-GTP•Met-tRNA(i) ternary complex (TC), which is recruited to the 40S ribosomal subunit. Following GTP hydrolysis, eIF2...

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Detalles Bibliográficos
Autores principales:	Bogorad, Andrew M., Lin, Kai Ying, Marintchev, Assen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714165/ https://www.ncbi.nlm.nih.gov/pubmed/29036434 http://dx.doi.org/10.1093/nar/gkx845

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