Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer’s disease?†

Evaluation of the pro versus antioxidant activity of ascorbate regarding Cu(Aβ) induced reactive oxygen species production in the context of Alzheimer’s disease shows that a protective activity can only be observed at high ascorbate concentration for exogenous molecules but not for the amyloid-β pep...

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Autores principales: Cheignon, Clémence, Collin, Fabrice, Faller, Peter, Hureau, Christelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714186/
https://www.ncbi.nlm.nih.gov/pubmed/27264439
http://dx.doi.org/10.1039/c6dt01979j
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author Cheignon, Clémence
Collin, Fabrice
Faller, Peter
Hureau, Christelle
author_facet Cheignon, Clémence
Collin, Fabrice
Faller, Peter
Hureau, Christelle
author_sort Cheignon, Clémence
collection PubMed
description Evaluation of the pro versus antioxidant activity of ascorbate regarding Cu(Aβ) induced reactive oxygen species production in the context of Alzheimer’s disease shows that a protective activity can only be observed at high ascorbate concentration for exogenous molecules but not for the amyloid-β peptide itself.
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spelling pubmed-57141862017-12-04 Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer’s disease?† Cheignon, Clémence Collin, Fabrice Faller, Peter Hureau, Christelle Dalton Trans Article Evaluation of the pro versus antioxidant activity of ascorbate regarding Cu(Aβ) induced reactive oxygen species production in the context of Alzheimer’s disease shows that a protective activity can only be observed at high ascorbate concentration for exogenous molecules but not for the amyloid-β peptide itself. 2016-08-09 /pmc/articles/PMC5714186/ /pubmed/27264439 http://dx.doi.org/10.1039/c6dt01979j Text en http://creativecommons.org/licenses/by-nc/3.0/ This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence (http://creativecommons.org/licenses/by-nc/3.0/) .
spellingShingle Article
Cheignon, Clémence
Collin, Fabrice
Faller, Peter
Hureau, Christelle
Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer’s disease?†
title Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer’s disease?†
title_full Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer’s disease?†
title_fullStr Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer’s disease?†
title_full_unstemmed Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer’s disease?†
title_short Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer’s disease?†
title_sort is ascorbate dr jekyll or mr hyde in the cu(aβ) mediated oxidative stress linked to alzheimer’s disease?†
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714186/
https://www.ncbi.nlm.nih.gov/pubmed/27264439
http://dx.doi.org/10.1039/c6dt01979j
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