Histone H1 depletion triggers an interferon response in cancer cells via activation of heterochromatic repeats

Histone H1 has seven variants in human somatic cells and contributes to chromatin compaction and transcriptional regulation. Knock-down (KD) of each H1 variant in breast cancer cells results in altered gene expression and proliferation differently in a variant specific manner with H1.2 and H1.4 KDs...

Descripción completa

Detalles Bibliográficos
Autores principales: Izquierdo-Bouldstridge, Andrea, Bustillos, Alberto, Bonet-Costa, Carles, Aribau-Miralbés, Patricia, García-Gomis, Daniel, Dabad, Marc, Esteve-Codina, Anna, Pascual-Reguant, Laura, Peiró, Sandra, Esteller, Manel, Murtha, Matthew, Millán-Ariño, Lluís, Jordan, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714221/
https://www.ncbi.nlm.nih.gov/pubmed/28977426
http://dx.doi.org/10.1093/nar/gkx746

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714221/
https://www.ncbi.nlm.nih.gov/pubmed/28977426
http://dx.doi.org/10.1093/nar/gkx746

Ejemplares similares