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Molecular mechanisms by which oxidative DNA damage promotes telomerase activity

Telomeres are highly susceptible to oxidative DNA damage, which if left unrepaired can lead to dysregulation of telomere length homeostasis. Here we employed single molecule FRET, single molecule pull-down and biochemical analysis to investigate how the most common oxidative DNA lesions, 8-oxoguanin...

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Detalles Bibliográficos
Autores principales:	Lee, Hui-Ting, Bose, Arindam, Lee, Chun-Ying, Opresko, Patricia L., Myong, Sua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714237/ https://www.ncbi.nlm.nih.gov/pubmed/28981887 http://dx.doi.org/10.1093/nar/gkx789

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