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Human Argonaute3 has slicer activity

Of the four human Argonaute (AGO) paralogs, only AGO2 has been shown to have slicer activity. The others (AGO1, AGO3 and AGO4) have been thought to assemble with microRNAs to form slicer-independent effector complexes that bind target mRNAs and silence gene expression through translational repressio...

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Detalles Bibliográficos
Autores principales:	Park, Mi Seul, Phan, Hong-Duc, Busch, Florian, Hinckley, Samantha H., Brackbill, James A., Wysocki, Vicki H., Nakanishi, Kotaro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714244/ https://www.ncbi.nlm.nih.gov/pubmed/29040713 http://dx.doi.org/10.1093/nar/gkx916

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