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Iron-induced oligomerization of human FXN(81-210) and bacterial CyaY frataxin and the effect of iron chelators

Patients suffering from the progressive neurodegenerative disease Friedreich’s ataxia have reduced expression levels of the protein frataxin. Three major isoforms of human frataxin have been identified, FXN(42-210), FXN(56-210) and FXN(81-210), of which FXN(81-210) is considered to be the mature for...

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Detalles Bibliográficos
Autores principales:	Ahlgren, Eva-Christina, Fekry, Mostafa, Wiemann, Mathias, Söderberg, Christopher A., Bernfur, Katja, Gakh, Olex, Rasmussen, Morten, Højrup, Peter, Emanuelsson, Cecilia, Isaya, Grazia, Al-Karadaghi, Salam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714350/ https://www.ncbi.nlm.nih.gov/pubmed/29200434 http://dx.doi.org/10.1371/journal.pone.0188937

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