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fluEvidenceSynthesis: An R package for evidence synthesis based analysis of epidemiological outbreaks

Public health related decisions often have to balance the cost of intervention strategies with the benefit of the reduction in disease burden. While the cost can often be inferred, forward modelling of the effect of different intervention options is complicated and disease specific. Here we introduc...

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Detalles Bibliográficos
Autores principales: van Leeuwen, Edwin, Klepac, Petra, Thorrington, Dominic, Pebody, Richard, Baguelin, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714397/
https://www.ncbi.nlm.nih.gov/pubmed/29155812
http://dx.doi.org/10.1371/journal.pcbi.1005838
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author van Leeuwen, Edwin
Klepac, Petra
Thorrington, Dominic
Pebody, Richard
Baguelin, Marc
author_facet van Leeuwen, Edwin
Klepac, Petra
Thorrington, Dominic
Pebody, Richard
Baguelin, Marc
author_sort van Leeuwen, Edwin
collection PubMed
description Public health related decisions often have to balance the cost of intervention strategies with the benefit of the reduction in disease burden. While the cost can often be inferred, forward modelling of the effect of different intervention options is complicated and disease specific. Here we introduce a package that is aimed to simplify this process. The package allows one to infer parameters using a Bayesian approach, perform forward modelling of the likely results of the proposed intervention and finally perform cost effectiveness analysis of the results. The package is based on a method previously used in the United Kingdom to inform vaccination strategies for influenza, with extensions to make it easily adaptable to other diseases and data sources.
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spelling pubmed-57143972017-12-15 fluEvidenceSynthesis: An R package for evidence synthesis based analysis of epidemiological outbreaks van Leeuwen, Edwin Klepac, Petra Thorrington, Dominic Pebody, Richard Baguelin, Marc PLoS Comput Biol Research Article Public health related decisions often have to balance the cost of intervention strategies with the benefit of the reduction in disease burden. While the cost can often be inferred, forward modelling of the effect of different intervention options is complicated and disease specific. Here we introduce a package that is aimed to simplify this process. The package allows one to infer parameters using a Bayesian approach, perform forward modelling of the likely results of the proposed intervention and finally perform cost effectiveness analysis of the results. The package is based on a method previously used in the United Kingdom to inform vaccination strategies for influenza, with extensions to make it easily adaptable to other diseases and data sources. Public Library of Science 2017-11-20 /pmc/articles/PMC5714397/ /pubmed/29155812 http://dx.doi.org/10.1371/journal.pcbi.1005838 Text en © 2017 van Leeuwen et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
van Leeuwen, Edwin
Klepac, Petra
Thorrington, Dominic
Pebody, Richard
Baguelin, Marc
fluEvidenceSynthesis: An R package for evidence synthesis based analysis of epidemiological outbreaks
title fluEvidenceSynthesis: An R package for evidence synthesis based analysis of epidemiological outbreaks
title_full fluEvidenceSynthesis: An R package for evidence synthesis based analysis of epidemiological outbreaks
title_fullStr fluEvidenceSynthesis: An R package for evidence synthesis based analysis of epidemiological outbreaks
title_full_unstemmed fluEvidenceSynthesis: An R package for evidence synthesis based analysis of epidemiological outbreaks
title_short fluEvidenceSynthesis: An R package for evidence synthesis based analysis of epidemiological outbreaks
title_sort fluevidencesynthesis: an r package for evidence synthesis based analysis of epidemiological outbreaks
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714397/
https://www.ncbi.nlm.nih.gov/pubmed/29155812
http://dx.doi.org/10.1371/journal.pcbi.1005838
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