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Flattening filter‐free linac improves treatment delivery efficiency in stereotactic body radiation therapy

Stereotactic body radiation therapy (SBRT) employs precision target tracking and image‐guidance techniques to deliver ablative doses of radiation to localized malignancies; however, treatment with conventional photon beams requires lengthy treatment and immobilization times. The use of flattening fi...

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Autores principales: Prendergast, Brendan M., Fiveash, John B., Popple, Richard A., Clark, Grant M., Thomas, Evan M., Minnich, Douglas J., Jacob, Rojymon, Spencer, Sharon A., Bonner, James A., Dobelbower, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714408/
https://www.ncbi.nlm.nih.gov/pubmed/23652246
http://dx.doi.org/10.1120/jacmp.v14i3.4126
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author Prendergast, Brendan M.
Fiveash, John B.
Popple, Richard A.
Clark, Grant M.
Thomas, Evan M.
Minnich, Douglas J.
Jacob, Rojymon
Spencer, Sharon A.
Bonner, James A.
Dobelbower, Michael C.
author_facet Prendergast, Brendan M.
Fiveash, John B.
Popple, Richard A.
Clark, Grant M.
Thomas, Evan M.
Minnich, Douglas J.
Jacob, Rojymon
Spencer, Sharon A.
Bonner, James A.
Dobelbower, Michael C.
author_sort Prendergast, Brendan M.
collection PubMed
description Stereotactic body radiation therapy (SBRT) employs precision target tracking and image‐guidance techniques to deliver ablative doses of radiation to localized malignancies; however, treatment with conventional photon beams requires lengthy treatment and immobilization times. The use of flattening filter‐free (FFF) beams operating at higher dose rates can shorten beam‐on time, and we hypothesize that it will shorten overall treatment delivery time. A total of 111 lung and liver SBRT cases treated at our institution from July 2008 to July 2011 were reviewed and 99 cases with complete data were identified. Treatment delivery times for cases treated with a FFF linac versus a conventional dose rate linac were compared. The frequency and type of intrafraction image guidance was also collected and compared between groups. Three hundred and ninety‐one individual SBRT fractions from 99 treatment plans were examined; 36 plans were treated with a FFF linac. In the FFF cohort, the mean ([Formula: see text]) treatment time (time elapsed from beam‐on until treatment end) and patient's immobilization time (time from first alignment image until treatment end) was [Formula: see text] and [Formula: see text] minutes compared to [Formula: see text] and [Formula: see text] minutes for the conventional cohort ([Formula: see text] for all values). Intrafraction‐computed tomography (CT) was used more often in the conventional cohort (84% vs. 25%; [Formula: see text]), but use of orthogonal X‐ray imaging remained the same (16% vs. 19%). For lung and liver SBRT, a FFF linac reduces treatment and immobilization time by more than 50% compared to a conventional linac. In addition, treatment with a FFF linac is associated with less physician‐ordered image guidance, which contributes to further improvement in treatment delivery efficiency. PACS number: 87.55.‐x
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spelling pubmed-57144082018-04-02 Flattening filter‐free linac improves treatment delivery efficiency in stereotactic body radiation therapy Prendergast, Brendan M. Fiveash, John B. Popple, Richard A. Clark, Grant M. Thomas, Evan M. Minnich, Douglas J. Jacob, Rojymon Spencer, Sharon A. Bonner, James A. Dobelbower, Michael C. J Appl Clin Med Phys Radiation Oncology Physics Stereotactic body radiation therapy (SBRT) employs precision target tracking and image‐guidance techniques to deliver ablative doses of radiation to localized malignancies; however, treatment with conventional photon beams requires lengthy treatment and immobilization times. The use of flattening filter‐free (FFF) beams operating at higher dose rates can shorten beam‐on time, and we hypothesize that it will shorten overall treatment delivery time. A total of 111 lung and liver SBRT cases treated at our institution from July 2008 to July 2011 were reviewed and 99 cases with complete data were identified. Treatment delivery times for cases treated with a FFF linac versus a conventional dose rate linac were compared. The frequency and type of intrafraction image guidance was also collected and compared between groups. Three hundred and ninety‐one individual SBRT fractions from 99 treatment plans were examined; 36 plans were treated with a FFF linac. In the FFF cohort, the mean ([Formula: see text]) treatment time (time elapsed from beam‐on until treatment end) and patient's immobilization time (time from first alignment image until treatment end) was [Formula: see text] and [Formula: see text] minutes compared to [Formula: see text] and [Formula: see text] minutes for the conventional cohort ([Formula: see text] for all values). Intrafraction‐computed tomography (CT) was used more often in the conventional cohort (84% vs. 25%; [Formula: see text]), but use of orthogonal X‐ray imaging remained the same (16% vs. 19%). For lung and liver SBRT, a FFF linac reduces treatment and immobilization time by more than 50% compared to a conventional linac. In addition, treatment with a FFF linac is associated with less physician‐ordered image guidance, which contributes to further improvement in treatment delivery efficiency. PACS number: 87.55.‐x John Wiley and Sons Inc. 2013-05-06 /pmc/articles/PMC5714408/ /pubmed/23652246 http://dx.doi.org/10.1120/jacmp.v14i3.4126 Text en © 2013 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Prendergast, Brendan M.
Fiveash, John B.
Popple, Richard A.
Clark, Grant M.
Thomas, Evan M.
Minnich, Douglas J.
Jacob, Rojymon
Spencer, Sharon A.
Bonner, James A.
Dobelbower, Michael C.
Flattening filter‐free linac improves treatment delivery efficiency in stereotactic body radiation therapy
title Flattening filter‐free linac improves treatment delivery efficiency in stereotactic body radiation therapy
title_full Flattening filter‐free linac improves treatment delivery efficiency in stereotactic body radiation therapy
title_fullStr Flattening filter‐free linac improves treatment delivery efficiency in stereotactic body radiation therapy
title_full_unstemmed Flattening filter‐free linac improves treatment delivery efficiency in stereotactic body radiation therapy
title_short Flattening filter‐free linac improves treatment delivery efficiency in stereotactic body radiation therapy
title_sort flattening filter‐free linac improves treatment delivery efficiency in stereotactic body radiation therapy
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714408/
https://www.ncbi.nlm.nih.gov/pubmed/23652246
http://dx.doi.org/10.1120/jacmp.v14i3.4126
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