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Performance evaluation of respiratory motion‐synchronized dynamic IMRT delivery

The purpose of this study was to evaluate the capabilities of DMLC to deliver the respiratory motion‐synchronized dynamic IMRT (MS‐IMRT) treatments under various dose rates. In order to create MS‐IMRT plans, the DMLC leaf motions in dynamic IMRT plans of eight lung patients were synchronized with th...

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Detalles Bibliográficos
Autores principales: Yoganathan, S.A., Das, K.J. Maria, Agarwal, Arpita, Kumar, Shaleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714411/
https://www.ncbi.nlm.nih.gov/pubmed/23652244
http://dx.doi.org/10.1120/jacmp.v14i3.4103
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author Yoganathan, S.A.
Das, K.J. Maria
Agarwal, Arpita
Kumar, Shaleen
author_facet Yoganathan, S.A.
Das, K.J. Maria
Agarwal, Arpita
Kumar, Shaleen
author_sort Yoganathan, S.A.
collection PubMed
description The purpose of this study was to evaluate the capabilities of DMLC to deliver the respiratory motion‐synchronized dynamic IMRT (MS‐IMRT) treatments under various dose rates. In order to create MS‐IMRT plans, the DMLC leaf motions in dynamic IMRT plans of eight lung patients were synchronized with the respiratory motion of breathing period 4 sec and amplitude 2 cm (peak to peak) using an in‐house developed leaf position modification program. The MS‐IMRT plans were generated for the dose rates of 100 MU/min, 400 MU/min, and 600 MU/min. All the MS‐IMRT plans were delivered in a medical linear accelerator, and the fluences were measured using a 2D ion chamber array, placed over a moving platform. The accuracy of MS‐IMRT deliveries was evaluated with respect to static deliveries (no compensation for target motion) using gamma test. In addition, the fluences of gated delivery of 30% duty cycle and non‐MS‐IMRT deliveries were also measured and compared with static deliveries. The MS‐IMRT was better in terms of dosimetric accuracy, compared to gated and non‐MS‐IMRT deliveries. The dosimetric accuracy was observed to be significantly better for 100 MU/min MS‐IMRT. However, the use of high‐dose rate in a MS‐IMRT delivery introduced dose‐rate modulation/beam hold‐offs that affected the synchronization between the DMLC leaf motion and target motion. This resulted in more dose deviations in MS‐IMRT deliveries at the dose rate of 600 MU/min. PACS numbers: 87.53.kn, 87.56.N‐
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spelling pubmed-57144112018-04-02 Performance evaluation of respiratory motion‐synchronized dynamic IMRT delivery Yoganathan, S.A. Das, K.J. Maria Agarwal, Arpita Kumar, Shaleen J Appl Clin Med Phys Radiation Oncology Physics The purpose of this study was to evaluate the capabilities of DMLC to deliver the respiratory motion‐synchronized dynamic IMRT (MS‐IMRT) treatments under various dose rates. In order to create MS‐IMRT plans, the DMLC leaf motions in dynamic IMRT plans of eight lung patients were synchronized with the respiratory motion of breathing period 4 sec and amplitude 2 cm (peak to peak) using an in‐house developed leaf position modification program. The MS‐IMRT plans were generated for the dose rates of 100 MU/min, 400 MU/min, and 600 MU/min. All the MS‐IMRT plans were delivered in a medical linear accelerator, and the fluences were measured using a 2D ion chamber array, placed over a moving platform. The accuracy of MS‐IMRT deliveries was evaluated with respect to static deliveries (no compensation for target motion) using gamma test. In addition, the fluences of gated delivery of 30% duty cycle and non‐MS‐IMRT deliveries were also measured and compared with static deliveries. The MS‐IMRT was better in terms of dosimetric accuracy, compared to gated and non‐MS‐IMRT deliveries. The dosimetric accuracy was observed to be significantly better for 100 MU/min MS‐IMRT. However, the use of high‐dose rate in a MS‐IMRT delivery introduced dose‐rate modulation/beam hold‐offs that affected the synchronization between the DMLC leaf motion and target motion. This resulted in more dose deviations in MS‐IMRT deliveries at the dose rate of 600 MU/min. PACS numbers: 87.53.kn, 87.56.N‐ John Wiley and Sons Inc. 2013-05-06 /pmc/articles/PMC5714411/ /pubmed/23652244 http://dx.doi.org/10.1120/jacmp.v14i3.4103 Text en © 2013 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Yoganathan, S.A.
Das, K.J. Maria
Agarwal, Arpita
Kumar, Shaleen
Performance evaluation of respiratory motion‐synchronized dynamic IMRT delivery
title Performance evaluation of respiratory motion‐synchronized dynamic IMRT delivery
title_full Performance evaluation of respiratory motion‐synchronized dynamic IMRT delivery
title_fullStr Performance evaluation of respiratory motion‐synchronized dynamic IMRT delivery
title_full_unstemmed Performance evaluation of respiratory motion‐synchronized dynamic IMRT delivery
title_short Performance evaluation of respiratory motion‐synchronized dynamic IMRT delivery
title_sort performance evaluation of respiratory motion‐synchronized dynamic imrt delivery
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714411/
https://www.ncbi.nlm.nih.gov/pubmed/23652244
http://dx.doi.org/10.1120/jacmp.v14i3.4103
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