Polymorphism in the Promoter Region of SEMA5A Is Associated with Sociality Traits in Korean Subjects with Autism Spectrum Disorders

In this study, we evaluated the association between autism spectrum disorders (ASDs) and 10 single-nucleotide polymorphisms (SNPs) in the 5' region of the semaphorin 5A gene (SEMA5A) for 250 Korean trios including children with ASDs. Family-based association testing and haplotype analysis revea...

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Autores principales: Kim, Soon Ae, Kim, Boong-Nyun, Kim, Jae-Won, Shin, Min-Sup, Park, Tae-Won, Son, Jung-Woo, Chung, Un-Sun, Park, Mira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714732/
https://www.ncbi.nlm.nih.gov/pubmed/29209394
http://dx.doi.org/10.4306/pi.2017.14.6.876
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author Kim, Soon Ae
Kim, Boong-Nyun
Kim, Jae-Won
Shin, Min-Sup
Park, Tae-Won
Son, Jung-Woo
Chung, Un-Sun
Park, Mira
author_facet Kim, Soon Ae
Kim, Boong-Nyun
Kim, Jae-Won
Shin, Min-Sup
Park, Tae-Won
Son, Jung-Woo
Chung, Un-Sun
Park, Mira
author_sort Kim, Soon Ae
collection PubMed
description In this study, we evaluated the association between autism spectrum disorders (ASDs) and 10 single-nucleotide polymorphisms (SNPs) in the 5' region of the semaphorin 5A gene (SEMA5A) for 250 Korean trios including children with ASDs. Family-based association testing and haplotype analysis revealed a statistically significant association between rs194085 and multiple sociality traits with Korean ASDs in the dominant model (p<0.001, corrected p=0.035). This indicates that genetic variations in the 5' region of SEMA5A play a role in the genetic predisposition to sociality traits in Korean ASDs.
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spelling pubmed-57147322017-12-05 Polymorphism in the Promoter Region of SEMA5A Is Associated with Sociality Traits in Korean Subjects with Autism Spectrum Disorders Kim, Soon Ae Kim, Boong-Nyun Kim, Jae-Won Shin, Min-Sup Park, Tae-Won Son, Jung-Woo Chung, Un-Sun Park, Mira Psychiatry Investig Brief Report In this study, we evaluated the association between autism spectrum disorders (ASDs) and 10 single-nucleotide polymorphisms (SNPs) in the 5' region of the semaphorin 5A gene (SEMA5A) for 250 Korean trios including children with ASDs. Family-based association testing and haplotype analysis revealed a statistically significant association between rs194085 and multiple sociality traits with Korean ASDs in the dominant model (p<0.001, corrected p=0.035). This indicates that genetic variations in the 5' region of SEMA5A play a role in the genetic predisposition to sociality traits in Korean ASDs. Korean Neuropsychiatric Association 2017-11 2017-11-07 /pmc/articles/PMC5714732/ /pubmed/29209394 http://dx.doi.org/10.4306/pi.2017.14.6.876 Text en Copyright © 2017 Korean Neuropsychiatric Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Kim, Soon Ae
Kim, Boong-Nyun
Kim, Jae-Won
Shin, Min-Sup
Park, Tae-Won
Son, Jung-Woo
Chung, Un-Sun
Park, Mira
Polymorphism in the Promoter Region of SEMA5A Is Associated with Sociality Traits in Korean Subjects with Autism Spectrum Disorders
title Polymorphism in the Promoter Region of SEMA5A Is Associated with Sociality Traits in Korean Subjects with Autism Spectrum Disorders
title_full Polymorphism in the Promoter Region of SEMA5A Is Associated with Sociality Traits in Korean Subjects with Autism Spectrum Disorders
title_fullStr Polymorphism in the Promoter Region of SEMA5A Is Associated with Sociality Traits in Korean Subjects with Autism Spectrum Disorders
title_full_unstemmed Polymorphism in the Promoter Region of SEMA5A Is Associated with Sociality Traits in Korean Subjects with Autism Spectrum Disorders
title_short Polymorphism in the Promoter Region of SEMA5A Is Associated with Sociality Traits in Korean Subjects with Autism Spectrum Disorders
title_sort polymorphism in the promoter region of sema5a is associated with sociality traits in korean subjects with autism spectrum disorders
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714732/
https://www.ncbi.nlm.nih.gov/pubmed/29209394
http://dx.doi.org/10.4306/pi.2017.14.6.876
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