ORAI channels are critical for receptor-mediated endocytosis of albumin

Impaired albumin reabsorption by proximal tubular epithelial cells (PTECs) has been highlighted in diabetic nephropathy (DN), but little is known about the underlying molecular mechanisms. Here we find that ORAI1-3, are preferentially expressed in PTECs and downregulated in patients with DN. Hypergl...

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Detalles Bibliográficos
Autores principales: Zeng, Bo, Chen, Gui-Lan, Garcia-Vaz, Eliana, Bhandari, Sunil, Daskoulidou, Nikoleta, Berglund, Lisa M., Jiang, Hongni, Hallett, Thomas, Zhou, Lu-Ping, Huang, Li, Xu, Zi-Hao, Nair, Viji, Nelson, Robert G., Ju, Wenjun, Kretzler, Matthias, Atkin, Stephen L., Gomez, Maria F., Xu, Shang-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714946/
https://www.ncbi.nlm.nih.gov/pubmed/29203863
http://dx.doi.org/10.1038/s41467-017-02094-y

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