TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut

The melastatin-like transient-receptor-potential-7 protein (TRPM7), harbouring a cation channel and a serine/threonine kinase, has been implicated in thymopoiesis and cytokine expression. Here we show, by analysing TRPM7 kinase-dead mutant (Trpm7 (R/R)) mice, that the enzymatic activity of the recep...

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Detalles Bibliográficos
Autores principales: Romagnani, Andrea, Vettore, Valentina, Rezzonico-Jost, Tanja, Hampe, Sarah, Rottoli, Elsa, Nadolni, Wiebke, Perotti, Michela, Meier, Melanie A., Hermanns, Constanze, Geiger, Sheila, Wennemuth, Gunther, Recordati, Camilla, Matsushita, Masayuki, Muehlich, Susanne, Proietti, Michele, Chubanov, Vladimir, Gudermann, Thomas, Grassi, Fabio, Zierler, Susanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714948/
https://www.ncbi.nlm.nih.gov/pubmed/29203869
http://dx.doi.org/10.1038/s41467-017-01960-z

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