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Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease
The abundance of mRNA is mainly determined by the rates of RNA transcription and decay. Here, we present a method for unbiased estimation of differential mRNA decay rate from RNA-sequencing data by modeling the kinetics of mRNA metabolism. We show that in all primary human tissues tested, and partic...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714957/ https://www.ncbi.nlm.nih.gov/pubmed/29030541 http://dx.doi.org/10.1038/s41467-017-00867-z |